CAJ | 학술논문

目的：观察替加环素联合头孢哌酮‐舒巴坦对广泛耐药鲍曼不动杆菌医院获得性肺炎的临床疗效。方法对东莞市第三人民医院的53例广泛耐药鲍曼不动杆菌医院获得性肺炎患者随机分为试验组（27例）和对照组（26例）。试验组给予替加环素联合头孢哌酮‐舒巴坦抗感染治疗，对照组单用替加环素，两组疗程均为14 d。结果治疗结束后，试验组有效率70．4％（19／27），明显高于对照组的38．5％（10／26）（ P＜0．05），但两组细菌清除率差异无统计学意义（55．6％对38．5％，P＞0．05）；两组不良反应的发生率差异也无统计学意义（14．3％对15．4％， P＞0．05）。结论大剂量的头孢哌酮‐舒巴坦可提高替加环素对广泛耐药鲍曼不动杆菌医院获得性肺炎的临床疗效，为临床治疗该类菌株感染提供了一种新的治疗策略。
목적：관찰체가배소연합두포고동‐서파탄대엄범내약포만불동간균의원획득성폐염적림상료효。방법대동완시제삼인민의원적53례엄범내약포만불동간균의원획득성폐염환자수궤분위시험조（27례）화대조조（26례）。시험조급여체가배소연합두포고동‐서파탄항감염치료，대조조단용체가배소，량조료정균위14 d。결과치료결속후，시험조유효솔70．4％（19／27），명현고우대조조적38．5％（10／26）（ P＜0．05），단량조세균청제솔차이무통계학의의（55．6％대38．5％，P＞0．05）；량조불량반응적발생솔차이야무통계학의의（14．3％대15．4％， P＞0．05）。결론대제량적두포고동‐서파탄가제고체가배소대엄범내약포만불동간균의원획득성폐염적림상료효，위림상치료해류균주감염제공료일충신적치료책략。
Objective To study the clinical efficacy of tigecycline in combination with cefoperazone‐sulbactam for treatment of hospital‐acquired pneumonia caused by extensively drug resistant Acinetobacter baumannii .Methods A total of 53 patients with hospital‐acquired pneumonia caused by extensively drug resistant A .baumannii were randomized to receive tigecycline plus cefoperazone‐sulbactam ,or tigecycline alone as control .The duration of treatment was 14 days for both groups .Results The combination therapy group was superior to control group in terms of overall efficacy rate(70 .4% vs 38 .5% ,P=0 .020) .The bacterial clearance rate (55 .6% vs 38 .5% ,P>0 .05)and incidence of adverse reactions (14 .3% vs 15 .4% ,P>0 .05)did not show significant difference between the two treatment groups .Conclusions High dose cefoperazone‐sulbactam can improve the antimicrobial activity of tigecycline in the treatment of hospital‐acquired pneumonia caused by extensively drug resistant A . baumannii ,which may be a new therapy strategy for such infections .