中国当代医药
中國噹代醫藥
중국당대의약
China Modern Medicine
2015年
27期
76-78
,共3页
万朝雷%魏玲%陈绪龙%王欢%洪进德%沈冬梅
萬朝雷%魏玲%陳緒龍%王歡%洪進德%瀋鼕梅
만조뢰%위령%진서룡%왕환%홍진덕%침동매
骨质疏松%注射型唑来膦酸盐%生活质量%骨代谢指标
骨質疏鬆%註射型唑來膦痠鹽%生活質量%骨代謝指標
골질소송%주사형서래련산염%생활질량%골대사지표
Osteoporosis%Injectable zoledronate%Quality of life%Bone metabolism
目的:观察注射型唑来膦酸盐对骨质疏松患者生活质量、骨代谢指标的影响。方法将九江市第一人民医院2013年2月~2014年2月收治的110例骨质疏松患者按随机数字表分为观察组55例和对照组55例,对照组给予钙剂与活性维生素D治疗,观察组在对照组的基础上再给予注射型唑来膦酸盐治疗,5 mg/次,1次/年,治疗前后空腹抽血,检测骨代谢指标,采用QUALEFFO-41量表评价生活质量改善情况。结果观察组治疗后碱性磷酸酶(ALP)、N-骨钙素(N-MID)、β-胶原片段(β-CTX)、I型前胶原氨基末端肽(PINP)较治疗前降低,差异有统计学意义(P<0.01),对照组治疗前后骨代谢指标差异无统计学意义(P>0.05),观察组治疗后ALP、N-MID、β-CTX、PINP明显低于对照组,差异有统计学意义(P<0.01)。观察组治疗后QUALEFFO-41量表中的疼痛、日常活动、家务劳动、日常运动、社会功能、总体情况、精神状态评分及总积分均较治疗前明显降低(P<0.05),对照组治疗前后上述指标无明显变化(P>0.05)。结论注射型唑来膦酸盐能有效改善患者生活质量及骨代谢指标,抑制破骨细胞活性,减少骨吸收,但其价格昂贵,临床医师应在药物疗效和经济性上进行合理选择。
目的:觀察註射型唑來膦痠鹽對骨質疏鬆患者生活質量、骨代謝指標的影響。方法將九江市第一人民醫院2013年2月~2014年2月收治的110例骨質疏鬆患者按隨機數字錶分為觀察組55例和對照組55例,對照組給予鈣劑與活性維生素D治療,觀察組在對照組的基礎上再給予註射型唑來膦痠鹽治療,5 mg/次,1次/年,治療前後空腹抽血,檢測骨代謝指標,採用QUALEFFO-41量錶評價生活質量改善情況。結果觀察組治療後堿性燐痠酶(ALP)、N-骨鈣素(N-MID)、β-膠原片段(β-CTX)、I型前膠原氨基末耑肽(PINP)較治療前降低,差異有統計學意義(P<0.01),對照組治療前後骨代謝指標差異無統計學意義(P>0.05),觀察組治療後ALP、N-MID、β-CTX、PINP明顯低于對照組,差異有統計學意義(P<0.01)。觀察組治療後QUALEFFO-41量錶中的疼痛、日常活動、傢務勞動、日常運動、社會功能、總體情況、精神狀態評分及總積分均較治療前明顯降低(P<0.05),對照組治療前後上述指標無明顯變化(P>0.05)。結論註射型唑來膦痠鹽能有效改善患者生活質量及骨代謝指標,抑製破骨細胞活性,減少骨吸收,但其價格昂貴,臨床醫師應在藥物療效和經濟性上進行閤理選擇。
목적:관찰주사형서래련산염대골질소송환자생활질량、골대사지표적영향。방법장구강시제일인민의원2013년2월~2014년2월수치적110례골질소송환자안수궤수자표분위관찰조55례화대조조55례,대조조급여개제여활성유생소D치료,관찰조재대조조적기출상재급여주사형서래련산염치료,5 mg/차,1차/년,치료전후공복추혈,검측골대사지표,채용QUALEFFO-41량표평개생활질량개선정황。결과관찰조치료후감성린산매(ALP)、N-골개소(N-MID)、β-효원편단(β-CTX)、I형전효원안기말단태(PINP)교치료전강저,차이유통계학의의(P<0.01),대조조치료전후골대사지표차이무통계학의의(P>0.05),관찰조치료후ALP、N-MID、β-CTX、PINP명현저우대조조,차이유통계학의의(P<0.01)。관찰조치료후QUALEFFO-41량표중적동통、일상활동、가무노동、일상운동、사회공능、총체정황、정신상태평분급총적분균교치료전명현강저(P<0.05),대조조치료전후상술지표무명현변화(P>0.05)。결론주사형서래련산염능유효개선환자생활질량급골대사지표,억제파골세포활성,감소골흡수,단기개격앙귀,림상의사응재약물료효화경제성상진행합리선택。
Objective To observe the influence of zoledronate on life quality and bone metabolism in the treatment of patients with osteoporosis. Methods 110 patients with osteoporosis from the First People’s Hospital of Jiujiang City were randomly divided into 55 cases of observation group and 55 cases of control group.The control group were re-ceived calcium and active vitamin D,the observation group were given injectable azole group on the basis of control group,5 mg/time,1 time/year,the bone metabolism was detected and the life quality was evaluated by QUALEFFO-41. Results The ALP,N-MID,β-CTX,PⅠNP of observation group after treatment was statistically lower than before treat-ment respectively,but the bone metabolism of control group before and after treatment was not statistically significant(P>0.05),theALP,N-MID,β-CTX,PⅠNP of observation group after treatment was statistically lower than that of control group respectively,the difference was statistically significant(P<0.01).The score of pain,daily activities,household chores, daily exercise,social function,the overall situation,mental state score and total score of observation group after treatment was significantly lower than before treatment respectively (P<0.05).The control group before and after treatment showed no significant change in the above(P>0.05). Conclusion Zoledronate can improve the life quality and bone metabolism, inhibit osteoclast activity,reduce bone resorption,but the clinicians should make a reasonable choice for its efficacy and economy,which has expensive treatment costs.