CAJ | 학술논문

内质网是调控细胞蛋白质合成、钙稳态和细胞凋亡的重要细胞器，内皮细胞具有高度发达的内质网，越来越多的研究发现内质网应激参与内皮细胞功能障碍。多种病理状态如高同型半胱氨酸血症、高血流剪切应力、高脂血症、高血糖等都可引起内皮细胞发生内质网应激，适当的内质网应激通过激活未折叠蛋白反应恢复内质网稳态，而内皮细胞内质网功能的长期损伤将导致慢性内质网应激和未折叠蛋白反应，进而增加内皮细胞氧化应激和炎性反应，最终致死亡。由于内皮细胞在维持血管稳态中作用关键，其收缩舒张功能障碍，且内皮细胞分泌的血管活性物质失衡，是多种血管性疾病发病的重要环节，尤其在体循环高血压和肺高血压病理生理过程中起着关键作用。
내질망시조공세포단백질합성、개은태화세포조망적중요세포기，내피세포구유고도발체적내질망，월래월다적연구발현내질망응격삼여내피세포공능장애。다충병리상태여고동형반광안산혈증、고혈류전절응력、고지혈증、고혈당등도가인기내피세포발생내질망응격，괄당적내질망응격통과격활미절첩단백반응회복내질망은태，이내피세포내질망공능적장기손상장도치만성내질망응격화미절첩단백반응，진이증가내피세포양화응격화염성반응，최종치사망。유우내피세포재유지혈관은태중작용관건，기수축서장공능장애，차내피세포분비적혈관활성물질실형，시다충혈관성질병발병적중요배절，우기재체순배고혈압화폐고혈압병리생리과정중기착관건작용。
Endoplasmic reticulum is an important organellein regulating protein synthesis, calcium homeostasis and apoptosis. It is known that endothelial cells have highly developed endoplasmic reticulum. Recently, a growing number of studies have found endoplasmic reticulum stress involved in endothelial dysfunction. A various pathological condi-tions including homocysteinemia, high blood flow shear stress, hyperlipidemia, high glucose can lead to endothelial dys-function in part through theactivation of ER stress. Proper endoplasmic reticulum stress helps maintain the balance of endoplasmic reticulum by activating unfolded protein response, whilechronic activation of ER stress and UPR pathways inendothelial cells causes a rise of oxidative stress andinflammatory responses, eventually lendingto cell death. En-dothelialcells play a crucial role in maintaining vascular homeostasis. It is theloss of normal systolic and diastolic func-tion and the imbalance of endothelial-cell- secreted vasoactive substances that result in a variety of vascular diseases, especially systemic hypertension and pulmonary arterial hypertension.