CAJ | 학술논문

谷氨酰胺（Glutamine，Gln）是体内最丰富的氨基酸，也是氨循环最主要的无毒载体，它是很多细胞生长所必需的，特别是对于快速生长的肿瘤细胞，Gln是其能量供应的主要来源。本文对肿瘤细胞中Gln代谢及其调控信号通路研究进展作一概述，并探讨了利用 Gln依赖这一特征作为某些肿瘤靶向治疗的可能性。
곡안선알（Glutamine，Gln）시체내최봉부적안기산，야시안순배최주요적무독재체，타시흔다세포생장소필수적，특별시대우쾌속생장적종류세포，Gln시기능량공응적주요래원。본문대종류세포중Gln대사급기조공신호통로연구진전작일개술，병탐토료이용 Gln의뢰저일특정작위모사종류파향치료적가능성。
ABSTRACT:Glutamine ( Glutamine,Gln) is the most abundant amino acid in vivo ,and also the main non-toxic car-rier of ammonia of Ammonia cycle ,which is necessary for the growth of many cells.As for the rapid growth of tumor cells,Gln is the main energy supply sources.This paper addresses the progress on the metabolism of glutamine in cancer cell,the signaling pathways that regulate the cellular utilization of glutamine ,and potential therapeutic strate-gies that might exploit the dependence of certain cancer cells on glutamine.