中国当代医药
中國噹代醫藥
중국당대의약
China Modern Medicine
2015年
27期
33-35,38
,共4页
杜华晟%程海%腊岩%孙莉娟
杜華晟%程海%臘巖%孫莉娟
두화성%정해%석암%손리연
血液净化%加贝酯%重症急性胰腺炎%临床疗效
血液淨化%加貝酯%重癥急性胰腺炎%臨床療效
혈액정화%가패지%중증급성이선염%림상료효
Blood Purification%Octreotide%Severe acute pancreatitis%Efficacy observation
目的：探讨血液净化联合加贝酯治疗重症急性胰腺炎的临床效果。方法选取2011年11月~2014年11月本院收治的114例重症急性胰腺炎患者作为研究对象，随机分为观察组与对照组，各57例。两组均给予常规治疗及持续性血液净化治疗，在此基础上观察组给予加贝酯进行治疗。比较两组体内的细胞因子水平（TNF-α、IL-6及IL-8）、APACHE-Ⅱ评分、腹痛消失时间、血清淀粉酶恢复时间、住院时间、临床疗效及安全性。结果观察组治疗后的TNF-α、IL-6、IL-8水平显著低于对照组治疗后，差异有统计学意义（P<0.05）。观察组治疗后的APACHE-Ⅱ评分显著低于对照组治疗后，腹痛消失时间、血清淀粉酶恢复时间及住院时间显著短于对照组，差异有统计学意义（P<0.05）。观察组的总有效率显著高于对照组，差异有统计学意义（P<0.05）。两组均未出现明显的不良反应。结论血液净化联合加贝酯治疗重症急性胰腺炎效果显著，值得临床推广应用。
目的：探討血液淨化聯閤加貝酯治療重癥急性胰腺炎的臨床效果。方法選取2011年11月~2014年11月本院收治的114例重癥急性胰腺炎患者作為研究對象，隨機分為觀察組與對照組，各57例。兩組均給予常規治療及持續性血液淨化治療，在此基礎上觀察組給予加貝酯進行治療。比較兩組體內的細胞因子水平（TNF-α、IL-6及IL-8）、APACHE-Ⅱ評分、腹痛消失時間、血清澱粉酶恢複時間、住院時間、臨床療效及安全性。結果觀察組治療後的TNF-α、IL-6、IL-8水平顯著低于對照組治療後，差異有統計學意義（P<0.05）。觀察組治療後的APACHE-Ⅱ評分顯著低于對照組治療後，腹痛消失時間、血清澱粉酶恢複時間及住院時間顯著短于對照組，差異有統計學意義（P<0.05）。觀察組的總有效率顯著高于對照組，差異有統計學意義（P<0.05）。兩組均未齣現明顯的不良反應。結論血液淨化聯閤加貝酯治療重癥急性胰腺炎效果顯著，值得臨床推廣應用。
목적：탐토혈액정화연합가패지치료중증급성이선염적림상효과。방법선취2011년11월~2014년11월본원수치적114례중증급성이선염환자작위연구대상，수궤분위관찰조여대조조，각57례。량조균급여상규치료급지속성혈액정화치료，재차기출상관찰조급여가패지진행치료。비교량조체내적세포인자수평（TNF-α、IL-6급IL-8）、APACHE-Ⅱ평분、복통소실시간、혈청정분매회복시간、주원시간、림상료효급안전성。결과관찰조치료후적TNF-α、IL-6、IL-8수평현저저우대조조치료후，차이유통계학의의（P<0.05）。관찰조치료후적APACHE-Ⅱ평분현저저우대조조치료후，복통소실시간、혈청정분매회복시간급주원시간현저단우대조조，차이유통계학의의（P<0.05）。관찰조적총유효솔현저고우대조조，차이유통계학의의（P<0.05）。량조균미출현명현적불량반응。결론혈액정화연합가패지치료중증급성이선염효과현저，치득림상추엄응용。
Objective To explore the clinical effect of combination of continuous blood purification and octreotide in the treatment of severe acute pancreatitis. Methods 114 cases of severe acute pancreatitis from November 2011 to November 2014 in our hospital were selected and randomly divided into the observation group and the control group,57 cases in each group.All patients were given conventional treatment and continuous blood purification therapy,on the ba-sis,the observation group was treated with octreotide.The cytokine level (TNF-α,IL-6 and IL-8),APACHE-II score,ab-dominal pain disappear time,serum amylase recovery time,hospital days,the clinical efficacy and safety in two groups was compared. Results The level of TNF-α,IL-6 and IL-8 of the observation group after treatment was lower than that of the control group after treatment,with significant difference (P<0.05).The APACHE-IIscore of the observation group was lower than that of the control group,abdominal pain disappear time,serum amylase recovery time and hospital days of the observation group was shorter than that of the control group,with significant difference(P<0.05).The total effective rate of the observation group was higher than that of the control group,with significant difference (P<0.05).There was no adverse reaction during treatment in two groups. Conclusion Continuous blood purification combined with octreotide in the treatment of severe acute pancreatitis is effective and safe,it is worthy of clinical promotion and application.
