CAJ | 학술논문

目的：探讨肿瘤转移抑制基因Kiss-1和蛋白水解酶D（cathepsin D，Cath-D）在胃癌中的表达及相关性，分析两者与胃癌转移、浸润的关系。方法收集2013年1月至2015年1月在内蒙古民族大学附属医院治疗的30例胃癌患者的胃癌组织与30例胃溃疡患者的正常胃黏膜组织，免疫组化检测两组标本中Kiss-1蛋白和Cath-D表达，同时分析在不同临床病理特征中二者表达及相关性。结果 Kiss-1蛋白正常胃黏膜组织中的阳性率为73.3％，在胃癌组织中的阳性率为46.7％，二者比较差异有统计学意义（P＜0.01），在不同病理特征中Kiss-1和Cath-D表达水平差异显著，有统计学意义（P＜0.05）。结论研究表明肿瘤转移抑制基因Kiss-1和Cath-D表达水平与胃癌的浸润、转移可能相关，对胃癌的发生、发展起重要作用，可能为胃癌的诊断、预后评估及基因治疗提供理论依据。
목적：탐토종류전이억제기인Kiss-1화단백수해매D（cathepsin D，Cath-D）재위암중적표체급상관성，분석량자여위암전이、침윤적관계。방법수집2013년1월지2015년1월재내몽고민족대학부속의원치료적30례위암환자적위암조직여30례위궤양환자적정상위점막조직，면역조화검측량조표본중Kiss-1단백화Cath-D표체，동시분석재불동림상병리특정중이자표체급상관성。결과 Kiss-1단백정상위점막조직중적양성솔위73.3％，재위암조직중적양성솔위46.7％，이자비교차이유통계학의의（P＜0.01），재불동병리특정중Kiss-1화Cath-D표체수평차이현저，유통계학의의（P＜0.05）。결론연구표명종류전이억제기인Kiss-1화Cath-D표체수평여위암적침윤、전이가능상관，대위암적발생、발전기중요작용，가능위위암적진단、예후평고급기인치료제공이론의거。
Objective To investigate expression and correlation of anti-metastasis gene Kiss-1 and Cath-D (cathepsin D) in gastric cancer tissue, and analyze relationship of them with metastasis and infiltration of gastric cancer.Method collect cancer tissue of 30 cases patients with gastric cancer treated in afifliated Hospital of Inner Mongolia Minzu University during January 2015 and January 2013, and normal gastric mucosa tissue of 30 cases gastric ulcer patients, and test by immunohistochemistry expression of Kiss-1 protein and Cath-D in two groups, and analyze their expression and correlation in different clinical pathological features.Result positive rate of Kiss-1 protein in normal gastric mucosa tissue was 73.3%, and that in gastric cancer tissue was 46.7%, difference between them showed statistical signiifcance (P< 0.01), and expression level of Kiss-1 and Cath-D in different pathological features showed signiifcant difference with statistics meaning (P < 0.05). Conclusionresearch shows 1expression level of anti-metastasis gene Kiss and Cath-D may have relations with inifltration and metastasis of gastric cancer, and may play an important role in occurrence and development of gastric cancer, which may provide theoretical basis for diagnosis, prognosis and gene therapy of gastric cancer.