CAJ | 학술논문

目的：探讨气体信号分子内源性硫化氢在支气管哮喘患儿血清中的表达情况及其与呼吸功能的相关性。方法选取2013年12月~2014年12月本院收治的50例支气管哮喘急性发作期患儿作为急性发作组,50例支气管哮喘缓解期患儿作为缓解组,选取同期的50例健康小儿作为对照组,采用敏感硫电极法检测血清硫化氢表达水平,采用肺功能检测仪检测各组呼吸功能,比较3组的内源性硫化氢表达水平及用力肺活量(FVC)、第一秒最大呼气率(FEV1%)、最大呼气中期流速(MMEF)等指标,分析急性发作期患儿FVC、FEV1%、MMEF与内源性硫化氢表达水平的相关性。结果急性发作组和缓解组的血清内源性硫化氢水平显著低于对照组,急性发作组的血清内源性硫化氢水平显著低于缓解组,差异有统计学意义(P<0.05)。急性发作组和缓解组的FVC、FEV1豫及MMEF水平显著低于对照组,急性发作组的FVC、FEV1豫及MMEF水平低于缓解组,差异具有统计学意义(P<0.05)。急性发作组内源性硫化氢表达水平同用力肺活量、第一秒最大呼气率、最大呼气中期流速呈现正相关。结论内源性硫化氢在支气管哮喘患儿中的表达水平降低,并且和呼吸功能相关,检测内源性硫化氢水平对于预测肺功能具有一定的临床意义。
목적：탐토기체신호분자내원성류화경재지기관효천환인혈청중적표체정황급기여호흡공능적상관성。방법선취2013년12월~2014년12월본원수치적50례지기관효천급성발작기환인작위급성발작조,50례지기관효천완해기환인작위완해조,선취동기적50례건강소인작위대조조,채용민감류전겁법검측혈청류화경표체수평,채용폐공능검측의검측각조호흡공능,비교3조적내원성류화경표체수평급용력폐활량(FVC)、제일초최대호기솔(FEV1%)、최대호기중기류속(MMEF)등지표,분석급성발작기환인FVC、FEV1%、MMEF여내원성류화경표체수평적상관성。결과급성발작조화완해조적혈청내원성류화경수평현저저우대조조,급성발작조적혈청내원성류화경수평현저저우완해조,차이유통계학의의(P<0.05)。급성발작조화완해조적FVC、FEV1예급MMEF수평현저저우대조조,급성발작조적FVC、FEV1예급MMEF수평저우완해조,차이구유통계학의의(P<0.05)。급성발작조내원성류화경표체수평동용력폐활량、제일초최대호기솔、최대호기중기류속정현정상관。결론내원성류화경재지기관효천환인중적표체수평강저,병차화호흡공능상관,검측내원성류화경수평대우예측폐공능구유일정적림상의의。
Objective To explore expressive level of endogenous hydrogen sulfide (H2S) in serum in children with bronchial asthma and its correlativity with respiratory function. Methods 50 children with bronchial asthma in acute at-tack stage from December 2013 to December 2014 in our hospital was selected as the acute attack group,50 children with bronchial asthma in remission stage were selected as the remission group and 50 cases of healthy children were selected as the control group during the same period.Endogenous H2S was detected with sensitive sulphur electrode and respiratory function was detected with lung function diagnostic system in every groups.The expression level of endoge-nous H2S,the index of forced vital capacity(FVC),forced expiratory volume in 1 second (FEV1%),maximal mid-expiratory flow (MMEF) among three groups was compared respectiveiy,and relativity of H2S with FVC,FEV1% and MMEF was an-alyzed in acute attack group. Results The level of H2S in the acute attack group and the remission group was lower than that in the control groups,with significant difference (P<0.05).The level of H2S in the acute attack group was lower than that in the remission group,with significant difference (P<0.05).The level of FVC,FEV1% and MMEF in the acute attack group and the remission group was lower than that in the control groups,with significant difference (P<0.05).The level of FVC,FEV1% and MMEF in the acute attack group was lower than that in the remission group,with significant difference (P<0.05).The level of H2S in serum was positive correlation with FVC,FEV1% and MMEF in acute attack group. Conclusion Expressive level of endogenous hydrogen sulfide in children with bronchial asthma is decreased,and which has correlative with respiratory function,detection of endogenous hydrogen sulfide has certain clinical signifi-cance for predicting lung function.