CAJ | 학술논문

目的：了解新生儿重症监护室(NICU)呼吸机相关肺炎(VAP)的病原菌特点、耐药性，探讨相应防治措施，为针对VAP 的抗菌药物治疗提供依据。方法以该院 NICU 收治的呼吸衰竭并行呼吸机辅助呼吸的80例患儿为研究对象，采用回顾性分析方法统计确诊为 VAP 的患儿临床资料、病原菌构成，并对患儿耐药情况进行分析。结果80例患儿中 VAP 发生率为43.75%(35/80)；共检出70株病原菌，以革兰阴性菌所占比例最高，占81.43%(57/70)；其中以铜绿假单胞菌、肺炎克雷伯菌所占比例较高；革兰阳性菌所占比例为18.57%(13/70)，其中以耐甲氧西林的金黄色葡萄球菌为主，除对万古霉素敏感外，对其余抗菌药物均耐药。结论新生儿 VAP 致病菌以革兰阴性菌为主，且病原菌均为多重耐药条件致病菌。
목적：료해신생인중증감호실(NICU)호흡궤상관폐염(VAP)적병원균특점、내약성，탐토상응방치조시，위침대VAP 적항균약물치료제공의거。방법이해원 NICU 수치적호흡쇠갈병행호흡궤보조호흡적80례환인위연구대상，채용회고성분석방법통계학진위 VAP 적환인림상자료、병원균구성，병대환인내약정황진행분석。결과80례환인중 VAP 발생솔위43.75%(35/80)；공검출70주병원균，이혁란음성균소점비례최고，점81.43%(57/70)；기중이동록가단포균、폐염극뢰백균소점비례교고；혁란양성균소점비례위18.57%(13/70)，기중이내갑양서림적금황색포도구균위주，제대만고매소민감외，대기여항균약물균내약。결론신생인 VAP 치병균이혁란음성균위주，차병원균균위다중내약조건치병균。
Objective To understand the characteristics of pathogenic bacteria and drug resistance of ventilator-associated pneu-monia(VAP)in neonatal intensive care unit (NICU),and to explore the corresponding prevention and control measures,and to pro-vide the basis for the VAP antibiotic treatment.Methods A total of 80 children with respiratory failure and ventilator assisted breathing were selected from the NICU as objects in this study.The clinical data,pathogenic bacteria and drug resistance were ana-lyzed retrospectively.Results In 80 cases,the incidence of VAP was 43.75% (35/80),a total of 70 strains of pathogenic bacteria were isolated,gram negative bacilli accounted for the highest proportion,accounting for 81.43% (57/70).Pseudomonas aeruginosa, Klebsiella pneumoniae were the most common gram negative bacilli.Gram positive cocci accounted for 8.57% (13/70),which domi-nated by methicillin resistant Staphylococcus aureus,in addition to susceptible to vancomycin,but resistant to the other antibiotics. Conclusion Gram negative bacillus are the main bacteria in VAP cases,and which are multiple drug-resistant pathogens.