CAJ | 학술논문

目的：了解紫杉醇载体的研究进展，为紫杉醇载体的研究以及紫杉醇的临床应用提供理论支持。方法通过对近些年紫杉醇载体相关研究的文献进行调研，了解紫杉醇载体的研究方向，并对各种载体的优缺点进行分析总结。结果紫杉醇作为一种有效的抗肿瘤化疗药物，但是水溶性差以及严重的毒性作用一定程度上限制了紫杉醇的广泛应用。脂质体、胶束、微球、纳米粒等新剂型的发展对打破这些限制，具有重要的意义。结论紫杉醇载体能够有效改善药物的溶解性，减轻毒副作用，并且向着多功能化和精细靶向方向发展。
목적：료해자삼순재체적연구진전，위자삼순재체적연구이급자삼순적림상응용제공이론지지。방법통과대근사년자삼순재체상관연구적문헌진행조연，료해자삼순재체적연구방향，병대각충재체적우결점진행분석총결。결과자삼순작위일충유효적항종류화료약물，단시수용성차이급엄중적독성작용일정정도상한제료자삼순적엄범응용。지질체、효속、미구、납미립등신제형적발전대타파저사한제，구유중요적의의。결론자삼순재체능구유효개선약물적용해성，감경독부작용，병차향착다공능화화정세파향방향발전。
Objective To understand the progress of paclitaxel carriers, to provide theoretical support for research of paclitaxel carriers and clinical use of paclitaxel.Methods To study literatures on paclitaxel carriers recently and understand the research direction of paclitaxel carriers.Subsequently, the advantages and disadvantages of various paclitaxel carriers were analyzed and summarized.Results Paclitaxel as an effective anti-tumor chemotherapy drugs, had poorly water-soluble, serious toxicity and side effects, which limited the wide application of paclitaxel to some degree.Development of liposomes, micelles, microspheres, nanoparticles and other new dosage forms had broken these restrictions, which had vital significance.Conclusion Paclitaxel carriers can improve the solubility of the drug, reduce side effects, and develop toward multi-functional and finely targeted.