现代肿瘤医学
現代腫瘤醫學
현대종류의학
Journal of Modern Oncology
2015年
23期
3429-3432
,共4页
陈健%沈彪%林兰%施民新%刘继斌
陳健%瀋彪%林蘭%施民新%劉繼斌
진건%침표%림란%시민신%류계빈
食管癌%ERCC2/XPD%XRCC1%基因多态性
食管癌%ERCC2/XPD%XRCC1%基因多態性
식관암%ERCC2/XPD%XRCC1%기인다태성
esophageal cancer%ERCC2 / XPD%XRCC1%genetic polymorphisms
目的:探讨 DNA 损伤修复基因 ERCC2/ XPD 和 XRCC1基因多态性与食管癌遗传易感性的关系。方法:采用病例对照研究设计,选取100例食管癌病例和80例正常对照。选取 ERCC2/ XPD Lys751Gln 和XRCC1 Arg399Gln 基因多态性为研究位点,以聚合酶链反应-限制性片段长度多态性(PCR - RFLP)方法进行多态性检测,应用 Logistic 回归计算 OR 值及95% CI,比较不同基因型与食管癌发病风险的关系。结果:病例组和对照组中变异型等位基因 ERCC2/ XPD Lys751Gln 的频率分别是15.7%和13.0%。与野生基因型Lys/ Lys 相比,携带 XPD Lys/ Gln 和 Gln/ Gln 基因型者患食管癌的危险度比值比(odds ratio,OR)分别是1.94(95% CI:1.22~3.36)和0.56(95% CI:0.15~2.64)。变异型等位基因 XRCC1399Gln 的频率在病例组和对照组中分别是29.8%和30.2%,与野生基因型 XRCC1 Arg/ Arg 相比,带 Arg / Gln 和 Gln / Gln 基因型者患食管癌的 OR 分别是0.94(95% CI:0.69~1.31)和1.83(95% CI:0.84~3.89)。分析结果提示饮酒、酸泡菜与XPD Lys751Gln 基因多态存在交互作用,交互效应 OR 值分别为2.24(95% CI:1.18~2.87)和2.53(95% CI:1.71~3.46),携带 XPD Lys751Gln 和 XRCC Arg1399Gln 突变基因者若同时暴露于酸泡菜或酒精,则患食管癌的危险显著增加,相较未暴露于上述因素者,OR 值均增大。结论:DNA 损伤修复基因 ERCC2/ XPD 和 XRCC1单核苷酸多态性可能与当地居民食管癌遗传易感性有关,与饮酒、酸泡菜存在交互作用。
目的:探討 DNA 損傷脩複基因 ERCC2/ XPD 和 XRCC1基因多態性與食管癌遺傳易感性的關繫。方法:採用病例對照研究設計,選取100例食管癌病例和80例正常對照。選取 ERCC2/ XPD Lys751Gln 和XRCC1 Arg399Gln 基因多態性為研究位點,以聚閤酶鏈反應-限製性片段長度多態性(PCR - RFLP)方法進行多態性檢測,應用 Logistic 迴歸計算 OR 值及95% CI,比較不同基因型與食管癌髮病風險的關繫。結果:病例組和對照組中變異型等位基因 ERCC2/ XPD Lys751Gln 的頻率分彆是15.7%和13.0%。與野生基因型Lys/ Lys 相比,攜帶 XPD Lys/ Gln 和 Gln/ Gln 基因型者患食管癌的危險度比值比(odds ratio,OR)分彆是1.94(95% CI:1.22~3.36)和0.56(95% CI:0.15~2.64)。變異型等位基因 XRCC1399Gln 的頻率在病例組和對照組中分彆是29.8%和30.2%,與野生基因型 XRCC1 Arg/ Arg 相比,帶 Arg / Gln 和 Gln / Gln 基因型者患食管癌的 OR 分彆是0.94(95% CI:0.69~1.31)和1.83(95% CI:0.84~3.89)。分析結果提示飲酒、痠泡菜與XPD Lys751Gln 基因多態存在交互作用,交互效應 OR 值分彆為2.24(95% CI:1.18~2.87)和2.53(95% CI:1.71~3.46),攜帶 XPD Lys751Gln 和 XRCC Arg1399Gln 突變基因者若同時暴露于痠泡菜或酒精,則患食管癌的危險顯著增加,相較未暴露于上述因素者,OR 值均增大。結論:DNA 損傷脩複基因 ERCC2/ XPD 和 XRCC1單覈苷痠多態性可能與噹地居民食管癌遺傳易感性有關,與飲酒、痠泡菜存在交互作用。
목적:탐토 DNA 손상수복기인 ERCC2/ XPD 화 XRCC1기인다태성여식관암유전역감성적관계。방법:채용병례대조연구설계,선취100례식관암병례화80례정상대조。선취 ERCC2/ XPD Lys751Gln 화XRCC1 Arg399Gln 기인다태성위연구위점,이취합매련반응-한제성편단장도다태성(PCR - RFLP)방법진행다태성검측,응용 Logistic 회귀계산 OR 치급95% CI,비교불동기인형여식관암발병풍험적관계。결과:병례조화대조조중변이형등위기인 ERCC2/ XPD Lys751Gln 적빈솔분별시15.7%화13.0%。여야생기인형Lys/ Lys 상비,휴대 XPD Lys/ Gln 화 Gln/ Gln 기인형자환식관암적위험도비치비(odds ratio,OR)분별시1.94(95% CI:1.22~3.36)화0.56(95% CI:0.15~2.64)。변이형등위기인 XRCC1399Gln 적빈솔재병례조화대조조중분별시29.8%화30.2%,여야생기인형 XRCC1 Arg/ Arg 상비,대 Arg / Gln 화 Gln / Gln 기인형자환식관암적 OR 분별시0.94(95% CI:0.69~1.31)화1.83(95% CI:0.84~3.89)。분석결과제시음주、산포채여XPD Lys751Gln 기인다태존재교호작용,교호효응 OR 치분별위2.24(95% CI:1.18~2.87)화2.53(95% CI:1.71~3.46),휴대 XPD Lys751Gln 화 XRCC Arg1399Gln 돌변기인자약동시폭로우산포채혹주정,칙환식관암적위험현저증가,상교미폭로우상술인소자,OR 치균증대。결론:DNA 손상수복기인 ERCC2/ XPD 화 XRCC1단핵감산다태성가능여당지거민식관암유전역감성유관,여음주、산포채존재교호작용。
Objective:To assess the relationship between ERCC2 / XPD and XRCC1 polymorphism and genetic susceptibility to esophageal cancer in a high risk Jiangsu population. Methods:A case - control study among 100 ES-CC cases and 80 controls matched by age and gender was conducted,and the genotypes were determined by the poly-merase chain reaction - restriction fragment length polymorphism(PCR - RFLP)assays. Logistic regression analysis was used to evaluate the odd ratios( ORs)and 95% confidence intervals( CIs)of ERCC2 / XPD Lys751Gln and XRCC1 Arg399Gln with susceptibility of ESCC. Results:The allele frequency for variant ERCC2 / XPD 751Gln in cases and controls were 15. 7% and 13. 0% respectively. The odds ratios for individuals carrying ERCC2 / XPD Lys/Gln and Gln/ Gln were 1. 94(95% CI:1. 22 ~ 3. 36)and 0. 56(95% CI:0. 15 ~ 2. 64). The allele frequency for vari-ant XRCC1 Arg399Gln in cases and controls were 15. 7% and 13% respectively. The odds ratios for individuals car-rying XRCC1 Arg399 Gln Arg / Gln and Gln / Gln were 0. 94(95% CI:0. 69 ~ 1. 31)and 1. 83(95% CI:0. 84 ~3. 89). A significant interaction was found between ERCC2 / XPD Lys751Gln polymorphism and alcohol or Sauerkraut in ESCC. Conclusion:Geneticpolymorphism of ERCC2 / XPD Lys/ Gln is associated with the susceptibility to esopha-geal squamous cell carcinoma.