现代肿瘤医学
現代腫瘤醫學
현대종류의학
Journal of Modern Oncology
2015年
23期
3489-3492
,共4页
黄晓峰%曲直%胡雯%张宁%王亚芳%王赟%张贺龙%刘理礼
黃曉峰%麯直%鬍雯%張寧%王亞芳%王赟%張賀龍%劉理禮
황효봉%곡직%호문%장저%왕아방%왕빈%장하룡%류리례
血管内皮抑素%化疗%转移性软组织肉瘤
血管內皮抑素%化療%轉移性軟組織肉瘤
혈관내피억소%화료%전이성연조직육류
endostatin%chemotherapy%metastasis soft tissue sarcoma
目的:探讨重组人血管内皮抑素联合化疗治疗转移性软组织肉瘤的疗效和安全性。方法:对20例诊断为晚期转移性软组织肉瘤的患者进行重组人血管内皮抑素(7.5mg/ m2,静滴,连续14天,21天为一周期)联合长春瑞滨(25mg/ m2,静滴,第1,8天)和顺铂(75mg/ m2,静滴,分开用,第1~3天)治疗,观察临床客观缓解率,近期疾病控制率、生活质量和不良反应。结果:2008年2月至2014年5月底,共入组20例。3例(15%)获得部分缓解,16例(80%)疾病稳定,1例(5%)疾病进展。客观有效率15%,近期疾病控制率(6个月)95%,15例生活质量改善,未发生重组人血管内皮抑素相关不良反应而导致的停药事件。结论:重组人血管内皮抑素联合化疗对软组织肉瘤有较好的抗肿瘤活性,耐受性好,值得扩大样本进一步研究。
目的:探討重組人血管內皮抑素聯閤化療治療轉移性軟組織肉瘤的療效和安全性。方法:對20例診斷為晚期轉移性軟組織肉瘤的患者進行重組人血管內皮抑素(7.5mg/ m2,靜滴,連續14天,21天為一週期)聯閤長春瑞濱(25mg/ m2,靜滴,第1,8天)和順鉑(75mg/ m2,靜滴,分開用,第1~3天)治療,觀察臨床客觀緩解率,近期疾病控製率、生活質量和不良反應。結果:2008年2月至2014年5月底,共入組20例。3例(15%)穫得部分緩解,16例(80%)疾病穩定,1例(5%)疾病進展。客觀有效率15%,近期疾病控製率(6箇月)95%,15例生活質量改善,未髮生重組人血管內皮抑素相關不良反應而導緻的停藥事件。結論:重組人血管內皮抑素聯閤化療對軟組織肉瘤有較好的抗腫瘤活性,耐受性好,值得擴大樣本進一步研究。
목적:탐토중조인혈관내피억소연합화료치료전이성연조직육류적료효화안전성。방법:대20례진단위만기전이성연조직육류적환자진행중조인혈관내피억소(7.5mg/ m2,정적,련속14천,21천위일주기)연합장춘서빈(25mg/ m2,정적,제1,8천)화순박(75mg/ m2,정적,분개용,제1~3천)치료,관찰림상객관완해솔,근기질병공제솔、생활질량화불량반응。결과:2008년2월지2014년5월저,공입조20례。3례(15%)획득부분완해,16례(80%)질병은정,1례(5%)질병진전。객관유효솔15%,근기질병공제솔(6개월)95%,15례생활질량개선,미발생중조인혈관내피억소상관불량반응이도치적정약사건。결론:중조인혈관내피억소연합화료대연조직육류유교호적항종류활성,내수성호,치득확대양본진일보연구。
Objective:To expolre the efficacy and safety of recombinant human endostatin combined with chemo-therapy in the treatment of metastasis soft tissue sarcoma. Methods:Twenty patients with pathologically confirmed me-tastasis soft tissue sarcoma received combined endostar(7. 5mg/ m2 ,d1 ~ 14 ,21d as a cycle)with vinorelbine(25mg/m2 ,d1,8 )and cisplatinum(75mg/ m2 ,d1 ~ 3 ). The clinical objective remission rate,disease control rate,quality of life (QOL)and adverse event were observed. Results:From 2008 February to 2014 May,20 cases were enrolled. 3 cases achieved partial remission(15% ),16 cases stable disease(80% ),1 case emerged disease progression(5% ). The ob-jective remission rate was 15% ,the disease control rate was 95% . 15 patients QOL were improved. The adverse event related endostar caused stop treatment was not happened. Conclusion:Combined endostar with chemotherapy in treat-ment of metastasis soft tissue sarcoma could control disease progression with well tolerance. More subjects shoule be enrolled for futher study.