CAJ | 학술논문

真核翻译起始因子（EIFs）是一类参与真核细胞蛋白质翻译起始过程并发挥不同作用的蛋白质。其家族成员大约有20余种，近年来研究发现，EIF 家族除了参与真核细胞蛋白质翻译起始进程外，其中多数成员在多种肿瘤细胞中存在过度表达或低表达，其表达量的异常与恶性肿瘤的发生、演化、预后关系及研究进展较为密切。
진핵번역기시인자（EIFs）시일류삼여진핵세포단백질번역기시과정병발휘불동작용적단백질。기가족성원대약유20여충，근년래연구발현，EIF 가족제료삼여진핵세포단백질번역기시진정외，기중다수성원재다충종류세포중존재과도표체혹저표체，기표체량적이상여악성종류적발생、연화、예후관계급연구진전교위밀절。
Eukaryotic translation initiation factors is a group of proteins involved in the initiation phase of eukaryotic translation and play different roles. There are about 20 family members in Eukaryotic translation initiation factors. Re-cently,it was revealed that EIFs are involved in in the initiation the phase of eukaryotic translation but also a majority of their members is overexpressed or underexpressed in many tumor cells. And its abnormal expression was closely as-sociated with the occurrence,evolution,prognosis and research progress of malignant tumor.