医学信息
醫學信息
의학신식
Medical Information
2015年
41期
125-126
,共2页
GIST%Cortactin%侵袭转移
GIST%Cortactin%侵襲轉移
GIST%Cortactin%침습전이
GIST%Cortactin%Invasion and metastasis
目的：通过检测GIST组织中Cortactin的表达情况，探讨其与GIST临床病理特征之间的关系，为预测该肿瘤的侵袭转移潜能提供理论依据。方法①采用免疫组化技术ELIVISION二步法检测42例GIST组织和10例正常胃组织中Cortactin蛋白表达情况；比较GIST组织中Cortactin蛋白的表达水平与其本身侵袭程度之间的关系；使用SPSS17.0软件对免疫组化结果进行统计学分析。结果 Cortactin在GIST组织中的表达明显高于正常胃组织(<0.001)，差异具有统计学意义。在GIST组织中Cortactin表达增高与GIST的肿瘤核分裂相、侵袭转移和高的NIH分级有关。Cortactin表达与GIST的NIH分级成正相关，即越高的NIH分级预示着Cortactin的表达越多(<0.01)。结论 Cortactin异常表达的程度可能与GIST的侵袭与转移有关，可能成为预测、评估GIST恶性潜能及肿瘤进展的重要指标，有望为临床治疗提供新的靶点。
目的：通過檢測GIST組織中Cortactin的錶達情況，探討其與GIST臨床病理特徵之間的關繫，為預測該腫瘤的侵襲轉移潛能提供理論依據。方法①採用免疫組化技術ELIVISION二步法檢測42例GIST組織和10例正常胃組織中Cortactin蛋白錶達情況；比較GIST組織中Cortactin蛋白的錶達水平與其本身侵襲程度之間的關繫；使用SPSS17.0軟件對免疫組化結果進行統計學分析。結果 Cortactin在GIST組織中的錶達明顯高于正常胃組織(<0.001)，差異具有統計學意義。在GIST組織中Cortactin錶達增高與GIST的腫瘤覈分裂相、侵襲轉移和高的NIH分級有關。Cortactin錶達與GIST的NIH分級成正相關，即越高的NIH分級預示著Cortactin的錶達越多(<0.01)。結論 Cortactin異常錶達的程度可能與GIST的侵襲與轉移有關，可能成為預測、評估GIST噁性潛能及腫瘤進展的重要指標，有望為臨床治療提供新的靶點。
목적：통과검측GIST조직중Cortactin적표체정황，탐토기여GIST림상병리특정지간적관계，위예측해종류적침습전이잠능제공이론의거。방법①채용면역조화기술ELIVISION이보법검측42례GIST조직화10례정상위조직중Cortactin단백표체정황；비교GIST조직중Cortactin단백적표체수평여기본신침습정도지간적관계；사용SPSS17.0연건대면역조화결과진행통계학분석。결과 Cortactin재GIST조직중적표체명현고우정상위조직(<0.001)，차이구유통계학의의。재GIST조직중Cortactin표체증고여GIST적종류핵분렬상、침습전이화고적NIH분급유관。Cortactin표체여GIST적NIH분급성정상관，즉월고적NIH분급예시착Cortactin적표체월다(<0.01)。결론 Cortactin이상표체적정도가능여GIST적침습여전이유관，가능성위예측、평고GIST악성잠능급종류진전적중요지표，유망위림상치료제공신적파점。
Objective Through detecting the expression of Cortactin in gastrointestinal stromal tumor(GIST)tissues to disscuss the relationship between the expression and clinicopathological feature and provide theoretical basis to predict the potentiality of invasion and metastasis of the tumor.Methods ①The expression of Cortactin in 42 cases of GIST tissues and 10 cases of normal gastric tissues were detected by immunohistochemical ELIVISION two-step method. ② The relation of the expression level of Cortactin and the invasion degree of tumor was compared in GIST. The immunohistochemical results were statistical y analyzed by the software of SPSS17.0.Results The expression of Cortactin in GIST was significantly higher than that in normal gastric tissues ( <0.001), The result was of statistical significance. The expression rate and intensity of Cortactin was significantly correlated to the pathological mitotic figures,invasion and metastasis,high NIH stage of GIST. The upregulated expression of Cortactin had positive cor elation with clinical NIH stage of GIST, that is to say the more advanced clinical NIH stage cor esponding to the higher expression level of Cortactin ( <0.01). Conclusion The abnormal expression level of Cortactin may be related to invasion and metastasis of GIST,it may be an important biomarker for predicting and evaluating the malignant potentiality and progression of GIST, hopeful y providing a new target for clinical treatment.
