国际眼科杂志
國際眼科雜誌
국제안과잡지
International Eye Science
2015年
11期
1949-1952
,共4页
张分队%王晶晶%高伟%朱海峰%龙潭%吴洁
張分隊%王晶晶%高偉%硃海峰%龍潭%吳潔
장분대%왕정정%고위%주해봉%룡담%오길
维生素A棕榈酸酯眼用凝胶%眼烧伤%眼表修复
維生素A棕櫚痠酯眼用凝膠%眼燒傷%眼錶脩複
유생소A종려산지안용응효%안소상%안표수복
vitamin A palmitate eye gel%ocular injuries%ocular surface reconstruction
目的::观察维生素A棕榈酸酯眼用凝胶对烧伤后早期眼表修复的临床疗效。方法:采用随机、双盲、阳性药物平行对照方法,将78例眼烧伤患者随机分为维生素A棕榈酸酯眼用凝胶治疗组( A组,40例),碱性成纤维细胞生长因子( bFGF)滴眼液治疗组( B 组,38例)。维生素 A 棕榈酸酯眼用凝胶和bFGF滴眼液均点眼4次/d,疗程为14d,观察两组的角膜上皮修复情况、干眼检查结果、症状及体征评分等指标。结果:维生素A棕榈酸酯眼用凝胶治疗组痊愈31例,显效5例,痊愈率为76%,有效率90%; bFGF治疗组痊愈32例,显效3例,痊愈率为84%,有效率为92%,两组之间无统计学差异(P >0.05),但维生素A棕榈酸酯眼用凝胶治疗组的Schirmer实验结果、泪膜破裂时间( BUT )与bFGF治疗组相比,均延长,两组之间有统计学差异( P<0.05);而且维生素A棕榈酸酯眼用凝胶治疗组患者的眼干、涩以及异物感的症状减轻程度明显好于bFGF治疗组,两者之间有统计学差异(P<0.05)。结论:维生素A棕榈酸酯眼用凝胶对烧伤后早期眼表修复疗效确切、应用方便。
目的::觀察維生素A棕櫚痠酯眼用凝膠對燒傷後早期眼錶脩複的臨床療效。方法:採用隨機、雙盲、暘性藥物平行對照方法,將78例眼燒傷患者隨機分為維生素A棕櫚痠酯眼用凝膠治療組( A組,40例),堿性成纖維細胞生長因子( bFGF)滴眼液治療組( B 組,38例)。維生素 A 棕櫚痠酯眼用凝膠和bFGF滴眼液均點眼4次/d,療程為14d,觀察兩組的角膜上皮脩複情況、榦眼檢查結果、癥狀及體徵評分等指標。結果:維生素A棕櫚痠酯眼用凝膠治療組痊愈31例,顯效5例,痊愈率為76%,有效率90%; bFGF治療組痊愈32例,顯效3例,痊愈率為84%,有效率為92%,兩組之間無統計學差異(P >0.05),但維生素A棕櫚痠酯眼用凝膠治療組的Schirmer實驗結果、淚膜破裂時間( BUT )與bFGF治療組相比,均延長,兩組之間有統計學差異( P<0.05);而且維生素A棕櫚痠酯眼用凝膠治療組患者的眼榦、澀以及異物感的癥狀減輕程度明顯好于bFGF治療組,兩者之間有統計學差異(P<0.05)。結論:維生素A棕櫚痠酯眼用凝膠對燒傷後早期眼錶脩複療效確切、應用方便。
목적::관찰유생소A종려산지안용응효대소상후조기안표수복적림상료효。방법:채용수궤、쌍맹、양성약물평행대조방법,장78례안소상환자수궤분위유생소A종려산지안용응효치료조( A조,40례),감성성섬유세포생장인자( bFGF)적안액치료조( B 조,38례)。유생소 A 종려산지안용응효화bFGF적안액균점안4차/d,료정위14d,관찰량조적각막상피수복정황、간안검사결과、증상급체정평분등지표。결과:유생소A종려산지안용응효치료조전유31례,현효5례,전유솔위76%,유효솔90%; bFGF치료조전유32례,현효3례,전유솔위84%,유효솔위92%,량조지간무통계학차이(P >0.05),단유생소A종려산지안용응효치료조적Schirmer실험결과、루막파렬시간( BUT )여bFGF치료조상비,균연장,량조지간유통계학차이( P<0.05);이차유생소A종려산지안용응효치료조환자적안간、삽이급이물감적증상감경정도명현호우bFGF치료조,량자지간유통계학차이(P<0.05)。결론:유생소A종려산지안용응효대소상후조기안표수복료효학절、응용방편。
Abstract?AlM: To evaluate the clinical effect of vitamin A palmitate eye gel on early ocular surface reconstruction after thermal or chemical injuries.?METHODS: Seventy - eight cases with thermal or chemical injuries to eyes were selected and divided into two groups by randomized, double-blind, positive drug parallel controlled method: group A ( 40 cases were treated with vitamin A palmitate eye gel ) and group B [ 38 cases were treated with basic fibroblast growth factor ( bFGF ) ] . The bFGF and vitamin A palmitate eye gel were used 4 times a day. The treatment course was 14d. Restoration of epithelial defect, Schirmer’s test values, tear break-up time ( BUT) , and subjective assessment of symptoms and signs were observed on D1, D3, D5, D7, D10 and D14.?RESULTS: ln group A, 31 cases were cured, 5 cases were effective, with the cure rate of 76% and efficiency 90%. ln group B, 32 cases were cured, 3 cases were effective, with the cure rate of 84% and efficiency 92%. There were no significant differences between the two groups ( P > 0. 05 ). However, there were significant differences on the results of Schirmer’s test and BUT ( P<0. 05), those in group A were expanded compared with group B. Symptoms of dry eye, astringent and foreign body sensation of group A were significantly better than those of group B, there were significant differences ( P<0. 05).?CONCLUSlON:Vitamin A palmitate eye gel is valuable and safe on early ocular surface reconstruction of the eyes suffered from thermal or chemical injuries.