CAJ | 학술논문

目的：通过给予糖耐量正常受试者不同类型脂肪酸饮食，探讨其对肠促胰岛素（ incretin ）、胰岛β细胞功能的影响。方法采用自身对照研究，15例健康受试者经标准饮食洗脱1周后，接受高饱和脂肪酸饮食（ HSF ）、高不饱和脂肪酸饮食（ HMF）之一作为早餐摄入，然后再采用标准饮食洗脱1周，重复试验过程，分别进食两种不同的营养餐。测定进餐后0、30、60、120、180、240 min血糖、血脂、游离脂肪酸、胰岛素、抑胃多肽（ gastric inhibitory poly-peptide， GIP）和胰高血糖素样肽-1（glucagon-like peptide-1，GLP-1）水平。评估不同类型脂肪酸对肠促胰岛素、胰岛β细胞功能的影响。结果曲线下面积（ AUC）分析，进餐后HSF组、HMF组血糖水平无明显改变，两组间差异无统计学意义（P＞0．05）。 HSF组与HMF组相比，AUCins240min、AUCTG240min和AUCFFA240min均增高，差异具有统计学意义（P＜0．05）。进餐后，HSF组与HMF组相比，AUCGIP30min、AUCGIP240min、AUCGLP-130min和AUCGLP-1240min均减低，差异有统计学意义（P＜0．05）。胰岛β细胞功能指数分析，两组间ΔI30／ΔG30差异无统计学意义（P＞0．05）。 HSF组与HMF组相比，AUCI／AUCG增高，差异有统计学意义（P＜0．05）。结论健康青年人群中不同类型脂肪酸饮食可影响GIP、GLP-1分泌及胰岛功能变化。此外，高不饱和脂肪酸饮食促进GIP、GLP-1分泌作用最明显，但高饱和脂肪酸饮食可促进更多胰岛素的分泌，胰岛β细胞功能指数也明显增高。
목적：통과급여당내량정상수시자불동류형지방산음식，탐토기대장촉이도소（ incretin ）、이도β세포공능적영향。방법채용자신대조연구，15례건강수시자경표준음식세탈1주후，접수고포화지방산음식（ HSF ）、고불포화지방산음식（ HMF）지일작위조찬섭입，연후재채용표준음식세탈1주，중복시험과정，분별진식량충불동적영양찬。측정진찬후0、30、60、120、180、240 min혈당、혈지、유리지방산、이도소、억위다태（ gastric inhibitory poly-peptide， GIP）화이고혈당소양태-1（glucagon-like peptide-1，GLP-1）수평。평고불동류형지방산대장촉이도소、이도β세포공능적영향。결과곡선하면적（ AUC）분석，진찬후HSF조、HMF조혈당수평무명현개변，량조간차이무통계학의의（P＞0．05）。 HSF조여HMF조상비，AUCins240min、AUCTG240min화AUCFFA240min균증고，차이구유통계학의의（P＜0．05）。진찬후，HSF조여HMF조상비，AUCGIP30min、AUCGIP240min、AUCGLP-130min화AUCGLP-1240min균감저，차이유통계학의의（P＜0．05）。이도β세포공능지수분석，량조간ΔI30／ΔG30차이무통계학의의（P＞0．05）。 HSF조여HMF조상비，AUCI／AUCG증고，차이유통계학의의（P＜0．05）。결론건강청년인군중불동류형지방산음식가영향GIP、GLP-1분비급이도공능변화。차외，고불포화지방산음식촉진GIP、GLP-1분비작용최명현，단고포화지방산음식가촉진경다이도소적분비，이도β세포공능지수야명현증고。
Objective To explore the effect of dietary fat acids on incretin and islet function in healthy adults .Methods Before each test, healthy subjects received a 1-week pre-experiment eucaloric diet .Fifteen subjects consumed two meals containing different fat acids , including high saturated fat acid ( HSF) and high monounsaturated fat acid ( HMF) .On two separate occasions,they underwent a minimum of 1-week washout between meals .At 0,30,60,120,180 and 240 min following meal intake, the plasma concentrations of gastric inhibitory polypeptide (GIP), glucagon-like peptide-1(GLP-1) and serum concentrations of glucose, insulin, triglycerides ( TG) and free fatty acid ( FFA) were measured.Results Postprandial glucose did not increase significantly following HSF and HMF meals (P>0.05).Compared with HMF meal, significant increase in AUCins240min,AUCTG240min and AUCFFA240minwas observed following HSF meal (P<0.05).Compared with HMF meal,a significant decrease in AUCGIP30min, AUCGIP240min, AUCGLP-1 30min and AUCGLP-1 240min was found following HSF meal (P<0.05).No significant difference was observed inΔI30/ΔG30 following HSF and HMF meals (P>0.05). AUCI/AUCG was significantly lower following HMF meal as compared with HSF meal (P<0.05).Conclusion This study demonstrates that the function of GIP ,GLP-1 andβcell is affected by the dietary fat acids in healthy adults .The HMF meal may stimulate GIP and GLP-1 secretion to a greater extent than HSF meal .