中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
19期
88-89
,共2页
丙泊酚%异氟烷%老年人%认知功能
丙泊酚%異氟烷%老年人%認知功能
병박분%이불완%노년인%인지공능
propofol%isoflurane%effects on cognitive function
目的：观察并比较丙泊酚与异氟烷全身麻醉对老年患者术后认知功能的影响。方法选择2013年1月至2014年12月医院收治的择期行腹部胃肠手术的老年患者68例，随机均分为丙泊酚组和异氟烷组。由同一医护人员采用简易精神状态量表（MMSE）于术前及术后1，6，12，24，48 h的分别检查评价认知功能。结果两组患者手术时间、麻醉时间差异无统计学意义（ P﹥0.05）；丙泊酚组患者术后自主呼吸恢复、睁眼、拔管和应答时间均比异氟烷组少（ P﹤0.05）；丙泊酚组12 h MMSE评分恢复至术前水平，异氟烷组于术后24 h恢复至术前水平（ P﹥0.05）；两组患者术后均有不良反应如恶心、呕吐和眩晕等不适症状出现，但丙泊酚组的发生率明显偏低( P﹤0.05)。丙泊酚组患者用药后可有效平稳维持心率和血压。结论丙泊酚和异氟烷均能影响老年手术患者的术后认知功能，但丙泊酚影响较小。
目的：觀察併比較丙泊酚與異氟烷全身痳醉對老年患者術後認知功能的影響。方法選擇2013年1月至2014年12月醫院收治的擇期行腹部胃腸手術的老年患者68例，隨機均分為丙泊酚組和異氟烷組。由同一醫護人員採用簡易精神狀態量錶（MMSE）于術前及術後1，6，12，24，48 h的分彆檢查評價認知功能。結果兩組患者手術時間、痳醉時間差異無統計學意義（ P﹥0.05）；丙泊酚組患者術後自主呼吸恢複、睜眼、拔管和應答時間均比異氟烷組少（ P﹤0.05）；丙泊酚組12 h MMSE評分恢複至術前水平，異氟烷組于術後24 h恢複至術前水平（ P﹥0.05）；兩組患者術後均有不良反應如噁心、嘔吐和眩暈等不適癥狀齣現，但丙泊酚組的髮生率明顯偏低( P﹤0.05)。丙泊酚組患者用藥後可有效平穩維持心率和血壓。結論丙泊酚和異氟烷均能影響老年手術患者的術後認知功能，但丙泊酚影響較小。
목적：관찰병비교병박분여이불완전신마취대노년환자술후인지공능적영향。방법선택2013년1월지2014년12월의원수치적택기행복부위장수술적노년환자68례，수궤균분위병박분조화이불완조。유동일의호인원채용간역정신상태량표（MMSE）우술전급술후1，6，12，24，48 h적분별검사평개인지공능。결과량조환자수술시간、마취시간차이무통계학의의（ P﹥0.05）；병박분조환자술후자주호흡회복、정안、발관화응답시간균비이불완조소（ P﹤0.05）；병박분조12 h MMSE평분회복지술전수평，이불완조우술후24 h회복지술전수평（ P﹥0.05）；량조환자술후균유불량반응여악심、구토화현훈등불괄증상출현，단병박분조적발생솔명현편저( P﹤0.05)。병박분조환자용약후가유효평은유지심솔화혈압。결론병박분화이불완균능영향노년수술환자적술후인지공능，단병박분영향교소。
Objective To observe the influence of propofol and isoflurane anesthesia on cognitive function in elderly patients after. Methods select January 2013 to December 2014 in our hospital undergoing gastrointestinal operation in elderly patients in 68 cases, were randomly divided into propofol group and isoflurane group. By the same medical workers using mini mental state examination ( MMSE ) incidence in the preoperative and postoperative 1, 6, 12, 24, 48 h respectively for patients with inspection and evaluation of cognitive function and POCD. Results the two groups of patients with operation, anesthesia with when the difference was not statistically significant ( P ﹥ 0. 05 );however, patients in the propofol group after spontaneous breathing recovery, eye opening, extubation and response time are compared with isoflurane group, the difference was statistically significant ( P ﹤ 0. 05 );Propofol group 12 h MMSE score level before restoration to the operation, isoflurane group after 24 h, recovered to the preoperative level ( P ﹥ 0. 05 );the two group patients after adverse reactions such as nausea, vomiting and dizziness have other symptoms, but propofol group the incidence rate was signifi-cantly lower, compared with statistical significance ( P ﹤ 0. 05 ) . The heart rate and blood pressure of the patients with propofol were ef-fective and stable after propofol use. Conclusion Propofol and isoflurane can cause the old POCD, but the effects of isoflurane propo-fol than low intensity.
