CAJ | 학술논문

目的：观察十一酸睾酮对骨质疏松老年男性患者骨量及骨代谢的影响。方法选择2013年1月至2014年12月收治的骨质疏松症患者100例，随机分为对照组和观察组，各50例。两组均给予钙剂、维生素D、降钙素等促进骨化抑制骨吸收的药物治疗，观察组加用十一酸睾酮。两组患者均以4周为1个疗程，治疗3个疗程。结果观察组总有效率为98.00%，高于对照组的86.00%（ P﹤0.05）。治疗前，两组患者腰椎正位、股骨颈的骨密度（BMD）、各项骨代谢指标无明显差异（ P﹥0.05）；治疗后，两组患者BMD、各项骨代谢指标均显著改善，且观察组改善情况显著优于对照组（ P﹤0.05）。两组患者不良反应均较轻，差异无统计学意义（ P﹥0.05）。结论十一酸睾酮对骨质疏松老年男性患者具有治疗作用，临床疗效显著，减轻疼痛，可影响患者骨量及骨代谢，且无明显不良反应发生，值得临床推广。
목적：관찰십일산고동대골질소송노년남성환자골량급골대사적영향。방법선택2013년1월지2014년12월수치적골질소송증환자100례，수궤분위대조조화관찰조，각50례。량조균급여개제、유생소D、강개소등촉진골화억제골흡수적약물치료，관찰조가용십일산고동。량조환자균이4주위1개료정，치료3개료정。결과관찰조총유효솔위98.00%，고우대조조적86.00%（ P﹤0.05）。치료전，량조환자요추정위、고골경적골밀도（BMD）、각항골대사지표무명현차이（ P﹥0.05）；치료후，량조환자BMD、각항골대사지표균현저개선，차관찰조개선정황현저우우대조조（ P﹤0.05）。량조환자불량반응균교경，차이무통계학의의（ P﹥0.05）。결론십일산고동대골질소송노년남성환자구유치료작용，림상료효현저，감경동통，가영향환자골량급골대사，차무명현불량반응발생，치득림상추엄。
Objective To observe the influence of testosterone undecanoate on bone mass and bone metabolism in elderly male patients with osteoporosis. Methods 100 cases of osteoporosis patients admitted to the hospital from January 2013 to December 2014 were ran-domly divided into the control group and the observation group, 50 cases in each group. The two groups were treated with calcium, vita-min D, calcitonin to promote ossification and inhibit bone absorption, and the observation group was added with testosterone unde-canoate. 4 weeks was 1 course of treatment and the two groups were treated for 3 courses. Results The total effective rate of the ob-servation group was 98. 00%, which was higher than 86. 00% in the control group ( P ﹤ 0. 05 ) . The lumbar spine and femoral neck BMD of the two groups had no significant difference before treatment, after treatment( P ﹥ 0. 05), the BMD of the two groups signifi-cantly improved, and the improvement of the observation group was significantly better than that of the control group. The bone metabolism of the two groups had no significant difference before treatment. After treatment, the bone metabolism of the two groups were significantly improved, and the improvement of the observation group was significantly better than that of the control group. The adverse reactions in the two groups were mild, and the difference between the incidence rate of the two groups was not statistically significant ( P ﹥ 0. 05 ) . Conclusion Testosterone undecanoate has a therapeutic effect in treating elderly male patients with osteoporosis; it has significant clinical effect, can affect bone mass and bone metabolism, reduce pain, with no significant adverse reactions, and thus is worth of clinical promotion.