中国药业
中國藥業
중국약업
China Pharmaceuticals
2015年
19期
19-20
,共2页
子宫腺肌病%左旋炔诺孕酮%宫内缓释节育系统%病灶阈值%疗效
子宮腺肌病%左鏇炔諾孕酮%宮內緩釋節育繫統%病竈閾值%療效
자궁선기병%좌선결낙잉동%궁내완석절육계통%병조역치%료효
adenomyosis%LNG%IUS%lesions threshold%effect
目的：探讨左旋炔诺孕酮宫内缓释节育系统（曼月乐，IUS）治疗子宫腺肌病有效的最大病灶阈值。方法根据子宫肌壁厚度或腺肌瘤最大直径( MD )将151例患者分为A组（MD≤25 mm，36例）、B组（25 mm﹤MD≤30 mm，42例）、C组（30 mm﹤MD≤35 mm，40例）、D组（MD﹥35 mm，33例），4组患者均于经期宫内放置IUS。结果较放置前，IUS放置后不同时段，A、B组痛经、月经量评分、子宫体积、CA125水平均明显下降（ P﹤0.05）；C组痛经、经量评分缓解明显（ P﹤0.05），但子宫体积、CA125下降不明显（ P﹥0.05）；D组痛经、经量评分、CA125和子宫体积均无明显变化（ P﹥0.05）。结论 IUS治疗子宫腺肌病存在病灶大小的选择性，其治疗有效的病灶阈值为MD≤35 mm。
目的：探討左鏇炔諾孕酮宮內緩釋節育繫統（曼月樂，IUS）治療子宮腺肌病有效的最大病竈閾值。方法根據子宮肌壁厚度或腺肌瘤最大直徑( MD )將151例患者分為A組（MD≤25 mm，36例）、B組（25 mm﹤MD≤30 mm，42例）、C組（30 mm﹤MD≤35 mm，40例）、D組（MD﹥35 mm，33例），4組患者均于經期宮內放置IUS。結果較放置前，IUS放置後不同時段，A、B組痛經、月經量評分、子宮體積、CA125水平均明顯下降（ P﹤0.05）；C組痛經、經量評分緩解明顯（ P﹤0.05），但子宮體積、CA125下降不明顯（ P﹥0.05）；D組痛經、經量評分、CA125和子宮體積均無明顯變化（ P﹥0.05）。結論 IUS治療子宮腺肌病存在病竈大小的選擇性，其治療有效的病竈閾值為MD≤35 mm。
목적：탐토좌선결낙잉동궁내완석절육계통（만월악，IUS）치료자궁선기병유효적최대병조역치。방법근거자궁기벽후도혹선기류최대직경( MD )장151례환자분위A조（MD≤25 mm，36례）、B조（25 mm﹤MD≤30 mm，42례）、C조（30 mm﹤MD≤35 mm，40례）、D조（MD﹥35 mm，33례），4조환자균우경기궁내방치IUS。결과교방치전，IUS방치후불동시단，A、B조통경、월경량평분、자궁체적、CA125수평균명현하강（ P﹤0.05）；C조통경、경량평분완해명현（ P﹤0.05），단자궁체적、CA125하강불명현（ P﹥0.05）；D조통경、경량평분、CA125화자궁체적균무명현변화（ P﹥0.05）。결론 IUS치료자궁선기병존재병조대소적선택성，기치료유효적병조역치위MD≤35 mm。
Objective To observe the effective lesion threshold of IUS in treating adenomyosis. Methods 151 cases of adenomyosis were divided into four groups according to the maximum diameter ( MD ) of uterine wall as follows:group A(MD≤25 mm, 36 cases), group B (25 mm ﹤ MD≤30 mm, 42 cases), group C (30 mm ﹤MD≤35 mm, 40 cases) and group D(MD ﹥35 mm, 33 cases). IUS were intrauterine placed within menstrual period in all four groups. The scale changes of menstrual quantity and dysmenorrhea, the uterine volumes and CA125 were contrastive analysis before and after IUS used in different observation time. Results The scale changes of the menstrual quantity and dysmenorrhea, the uterine volumes and CA125 were significant in different observation time after IUS were used both in group A and B( P ﹤ 0. 05);while in group C, the changes were only observed in scales of menstrual quantity and dysmenor-rhea( P ﹤ 0. 05), although the uterine volumes and CA125 dropped in some degree, but no significance were observed in the period of this research( P ﹥ 0. 05). No obvious varieties of the observation index mentioned above were found in group D ( P ﹥ 0. 05 ) . Conclusion The effective lesion threshold for treating adenomyosis exists a selectivity, and the threshold value is less than 35 mm.
