CAJ | 학술논문

结膜中的血管过度生长并延伸入角膜形成角膜新生血管( corneal neovascularization, CNV)。血管的异常增生通常来源于角膜受损及自我修复,这是新生血管形成的重要过程。血管的病理性增生阻碍光在眼球内的传播,促进瘢痕形成并引起炎症反应。角膜新生血管会严重影响视力,甚至导致失明。新生血管性眼病是临床上最常见的问题之一。因此进一步的角膜新生血管机制研究是防治新生血管性眼病的关键。角膜新生血管动物模型的选择对研究具有重要意义。本文主要就几种角膜新生血管模型的制备方法作一综述。
결막중적혈관과도생장병연신입각막형성각막신생혈관( corneal neovascularization, CNV)。혈관적이상증생통상래원우각막수손급자아수복,저시신생혈관형성적중요과정。혈관적병이성증생조애광재안구내적전파,촉진반흔형성병인기염증반응。각막신생혈관회엄중영향시력,심지도치실명。신생혈관성안병시림상상최상견적문제지일。인차진일보적각막신생혈관궤제연구시방치신생혈관성안병적관건。각막신생혈관동물모형적선택대연구구유중요의의。본문주요취궤충각막신생혈관모형적제비방법작일종술。
Abstract?Corneal neovascularization ( CNV ) is the extensive growth of blood vessels from conjunctiva into cornea. Abnormal angiogenesis plays an important role in the process of CNV, which may result from corneal wound and self-healing. The pathologic growth of blood vessels blocks light, promotes scar formation and causes inflammation, which impairs visual acuity. lt is a sight-threatening condition that can decreases eyesight and even leads to blindness. Neovascular eye disease is one of the most common eye diseases in clinical admissions. So, further mechanistic studies are the key to the prevention and treatment of CNV. Determination on the CNV animal models is essential in eye diseases researches. Several main methods of CNV models establishment are summarized in this review.