国际眼科杂志
國際眼科雜誌
국제안과잡지
International Eye Science
2015年
11期
1956-1959
,共4页
人工泪液%睑板腺功能障碍%干眼症%敏感度
人工淚液%瞼闆腺功能障礙%榦眼癥%敏感度
인공루액%검판선공능장애%간안증%민감도
artificial tears%Meibomian gland dysfunction%dry eyes%sensitivity
目的：观察人工泪液在应用综合疗法治疗中老年睑板腺功能障碍( Meibomian gland dysfunction,MGD)所致干眼症的治疗前后对比敏感度的变化情况,评价人工泪液对中老年MGD所致干眼症患者视功能的影响。方法：筛选2014-06-01/2015-01-30我院眼科诊治首次确诊为MGD所致干眼症的中老年患者120例240眼。选取60例120眼正常人为正常组。根据研究纳入标准将120例MGD所致干眼症患者按照数字随机表法随机均分为观察组与对照组。观察组治疗方案：选用人工泪液滴眼液规律滴眼、按摩等局部治疗,联合全身治疗,对照组不使用人工泪液滴眼液,正常组不采取任何治疗。观察组及对照的治疗疗程均为16wk,疗程结束后随访8wk。对观察指标进行观察、比较。结果：观察组有效率95.8%明显高于对照组83.3%,具有统计学意义(χ2=10.05,P=0.002)；观察组 BUT(3.14±2.01s)、SⅠt (4.56±1.86mm )与对照组 BUT (2.54±1.01s)、SⅠt (3.48±1.23mm)、正常组 BUT (12.85± ；2.34s)、SⅠt(15.36±2.48mm),三组间差异有统计学意义,但观察组与对照组组间差异无统计学意义(P>0.05)；人工泪液使用前观察组、对照组MGD所致干眼患者的低、中、高频敏感度均低于正常人的正常组( P<0.05)；而使用人工泪液滴眼前,观察组、对照组患者的对比敏感度差异无统计学意义(P>0.05),观察组患者用人工泪液滴眼后,观察组患者各频段(1.8、3.0、6.0、12、18、24c/d)对比敏感度明显高于对照组患者,具有统计学差异( P<0.05)。结论：MGD所致干眼症患者在经过综合疗法治疗并辅助以人工泪液滴眼能够明显使干眼症患者的对比敏感度提高、缓解干眼症患者自觉不适症状、提高视觉质量。另外,对比敏感度测定作为一种非接触性的客观检查手段,可为药物治疗中老年MGD所致干眼症的疗效、诊断提供客观依据。
目的：觀察人工淚液在應用綜閤療法治療中老年瞼闆腺功能障礙( Meibomian gland dysfunction,MGD)所緻榦眼癥的治療前後對比敏感度的變化情況,評價人工淚液對中老年MGD所緻榦眼癥患者視功能的影響。方法：篩選2014-06-01/2015-01-30我院眼科診治首次確診為MGD所緻榦眼癥的中老年患者120例240眼。選取60例120眼正常人為正常組。根據研究納入標準將120例MGD所緻榦眼癥患者按照數字隨機錶法隨機均分為觀察組與對照組。觀察組治療方案：選用人工淚液滴眼液規律滴眼、按摩等跼部治療,聯閤全身治療,對照組不使用人工淚液滴眼液,正常組不採取任何治療。觀察組及對照的治療療程均為16wk,療程結束後隨訪8wk。對觀察指標進行觀察、比較。結果：觀察組有效率95.8%明顯高于對照組83.3%,具有統計學意義(χ2=10.05,P=0.002)；觀察組 BUT(3.14±2.01s)、SⅠt (4.56±1.86mm )與對照組 BUT (2.54±1.01s)、SⅠt (3.48±1.23mm)、正常組 BUT (12.85± ；2.34s)、SⅠt(15.36±2.48mm),三組間差異有統計學意義,但觀察組與對照組組間差異無統計學意義(P>0.05)；人工淚液使用前觀察組、對照組MGD所緻榦眼患者的低、中、高頻敏感度均低于正常人的正常組( P<0.05)；而使用人工淚液滴眼前,觀察組、對照組患者的對比敏感度差異無統計學意義(P>0.05),觀察組患者用人工淚液滴眼後,觀察組患者各頻段(1.8、3.0、6.0、12、18、24c/d)對比敏感度明顯高于對照組患者,具有統計學差異( P<0.05)。結論：MGD所緻榦眼癥患者在經過綜閤療法治療併輔助以人工淚液滴眼能夠明顯使榦眼癥患者的對比敏感度提高、緩解榦眼癥患者自覺不適癥狀、提高視覺質量。另外,對比敏感度測定作為一種非接觸性的客觀檢查手段,可為藥物治療中老年MGD所緻榦眼癥的療效、診斷提供客觀依據。
목적：관찰인공루액재응용종합요법치료중노년검판선공능장애( Meibomian gland dysfunction,MGD)소치간안증적치료전후대비민감도적변화정황,평개인공루액대중노년MGD소치간안증환자시공능적영향。방법：사선2014-06-01/2015-01-30아원안과진치수차학진위MGD소치간안증적중노년환자120례240안。선취60례120안정상인위정상조。근거연구납입표준장120례MGD소치간안증환자안조수자수궤표법수궤균분위관찰조여대조조。관찰조치료방안：선용인공루액적안액규률적안、안마등국부치료,연합전신치료,대조조불사용인공루액적안액,정상조불채취임하치료。관찰조급대조적치료료정균위16wk,료정결속후수방8wk。대관찰지표진행관찰、비교。결과：관찰조유효솔95.8%명현고우대조조83.3%,구유통계학의의(χ2=10.05,P=0.002)；관찰조 BUT(3.14±2.01s)、SⅠt (4.56±1.86mm )여대조조 BUT (2.54±1.01s)、SⅠt (3.48±1.23mm)、정상조 BUT (12.85± ；2.34s)、SⅠt(15.36±2.48mm),삼조간차이유통계학의의,단관찰조여대조조조간차이무통계학의의(P>0.05)；인공루액사용전관찰조、대조조MGD소치간안환자적저、중、고빈민감도균저우정상인적정상조( P<0.05)；이사용인공루액적안전,관찰조、대조조환자적대비민감도차이무통계학의의(P>0.05),관찰조환자용인공루액적안후,관찰조환자각빈단(1.8、3.0、6.0、12、18、24c/d)대비민감도명현고우대조조환자,구유통계학차이( P<0.05)。결론：MGD소치간안증환자재경과종합요법치료병보조이인공루액적안능구명현사간안증환자적대비민감도제고、완해간안증환자자각불괄증상、제고시각질량。령외,대비민감도측정작위일충비접촉성적객관검사수단,가위약물치료중노년MGD소치간안증적료효、진단제공객관의거。
Abstract?AlM:To observe the change of contrast sensitivity in the middle and the old with dry eyes caused by Meibomian gland dysfunction ( MGD ) before and after using the artificial tears in the comprehensive therapy and to evaluate the influence of artificial tears on visual function in these patients.?METHODS:One hundred and twenty middle aged and old patients ( 240 eyes ) who were diagnosed with dry eyes caused by MGD for the first time in our department from June 1st 2014 to January 30st 2015 were screened. Sixty ( 120 eyes ) normal people were chosen as normal group. The 120 patients enrolled through inclusion criteria were divided into observation group and control group by random digits table. The patients in observation group were treated with artificial tears regularly combined with local massage and systemic treatment. Patients in control group were treated the same as those in the observation group except artificial tears. Normal group did not receive any treatment. The treatments for both observation group and control group lasted for 16wk. The follow-up period after treatment was 8wk. Observe and compare the contrast sensitivity.? RESULTS: Effective rate of observation group was 83. 3%, which was obviously higher than that of control group 95. 8%,the difference was statistically significant (χ2=10. 05, P = 0. 002 ). BUT of observation group, control group and normal group were 3. 14±2. 01s, 2. 54±1. 01s and 12. 85 ± 2. 34s respectively. SⅠt of observation group, control group and normal group were 4. 56±1. 86mm, 3. 48± 1. 23mm and 15. 36 ± 2. 48mm respectively. There was statistic significance on the two terms among the three groups. But the difference between observation group and control group was not significant. Before treatments, contrast sensitivity at low, middle and high frequency of both observation group and control group was lower than those of normal group (P<0. 05),but there was no statistic significance between observation group and control group (P > 0. 05 ). After treated by artificial tears, contrast sensitivity of observation group at different frequency ( 1. 8c/d, 3. 0c/d, 6. 0c/d, 12c/d, 18c/d, 24c/d ) was obviously higher than those of control group, and the difference was statistically significant(P<0. 05).?CONCLUSlON: After comprehensive therapy combined with artificial tears, the patients with dry eyes caused by MGD have better contrast sensitivity. The subjective symptoms are relieved. The visual acuity is improved. Besides, contrast sensitivity as a non-contact objective examination, can proved evidence to diagnosis and effect evaluation for the patients after treatments.
