CAJ | 학술논문

肠道微生物对人体健康有着重要的作用，与营养物质吸收和肥胖、糖尿病等代谢性疾病关系密切。从肠道微生物的角度研究疾病发生及防治方法已成热点。高等动物模型存在个体差异大、肠道微生物种类繁多、数量庞大、影响因素多变等弊端。秀丽隐杆线虫（ Caenorhabditis elegans），简称线虫，是研究肠道微生物和宿主之间相互作用的良好模式生物，其以大肠杆菌为食物，具有生长周期短、表型易于观察、可实现药物的高通量筛选等优点。如利用线虫模型筛选具有抗致病菌感染的益生菌，同时揭示多种细菌间的相互作用机制。该文对秀丽线虫在肠道微生物与宿主共生关系及相关应用研究进展进行综述。
장도미생물대인체건강유착중요적작용，여영양물질흡수화비반、당뇨병등대사성질병관계밀절。종장도미생물적각도연구질병발생급방치방법이성열점。고등동물모형존재개체차이대、장도미생물충류번다、수량방대、영향인소다변등폐단。수려은간선충（ Caenorhabditis elegans），간칭선충，시연구장도미생물화숙주지간상호작용적량호모식생물，기이대장간균위식물，구유생장주기단、표형역우관찰、가실현약물적고통량사선등우점。여이용선충모형사선구유항치병균감염적익생균，동시게시다충세균간적상호작용궤제。해문대수려선충재장도미생물여숙주공생관계급상관응용연구진전진행종술。
Gut microbes play an important role in human health and are believed to be closely related to obesity , diabetes and some other metabolic diseases .Recently, intestinal flora has become a research hotspot and new target for disease prevention.The problems facing intestinal flora research included variability between individuals ,huge amounts and varieties of gut microbes .Caenorhabditis elegans, with the advantages of living on E.coli, short growth periods , easy observation,applicability to high throughput screening of drugs , is an ideal model organism for research of microbe-host interactions .It has been used in probiotics screening and interaction mechanism research of multifold bacteria .This review summarizes some new researches and applications in this area .