医学信息
醫學信息
의학신식
Medical Information
2015年
43期
161-162
,共2页
变应性鼻炎%鼻分泌物%嗜酸性粒细胞
變應性鼻炎%鼻分泌物%嗜痠性粒細胞
변응성비염%비분비물%기산성립세포
Al ergic rhinitis%Nasal secretion%Eosnophils
目的探讨儿童变应性鼻炎(al ergic rhinitis,AR)患者在接受丙酸氟替卡松鼻喷雾剂治疗前后鼻分泌物涂片中嗜酸性粒细胞(eosnophils,EOS)百分比的变化。方法收集由本院确诊的持续性AR患儿(近1个月内未接受任何糖皮质激素类药物治疗)60例为研究对象,均给予丙酸氟替卡松鼻喷雾剂治疗,对其治疗前及治疗4w和8w后分别检查其鼻分泌物中EOS的百分比,观察其变化。同时对AR患儿治疗前及治疗4w和8w后进行变应性鼻结膜炎症状视觉模拟评分判定疗效。结果①治疗前鼻分泌物中EOS百分比重度(跃0.50)的AR患儿44例,经丙酸氟替卡松鼻喷雾剂治疗4w 31例鼻分泌物中EOS百分比下降,治疗8w 42例鼻分泌物中EOS百分比下降,治疗8w鼻分泌物中EOS百分比的下降率显著高于治疗4w,差异有统计学意义(字2=9.724,=0.003<0.05)；治疗前鼻分泌物中EOS百分比中度(跃0.10-0.50)的AR患儿11例,经治疗4w 6例鼻分泌物中EOS百分比下降,治疗8w 10例鼻分泌物中EOS百分比下降,治疗4w与治疗8w鼻分泌物中EOS百分比下降率无统计学意义差异(字2=3.667,=0.149跃0.05)。②60例AR患儿经丙酸氟替卡松鼻喷雾剂治疗4w的有效率为80.00%,治疗8w的有效率为93.33%,治疗8w的有效率高于治疗4w的有效率,差异有统计学意义(字2=4.615,=0.032)。结论丙酸氟替卡松鼻喷雾剂治疗儿童AR能迅速降低患儿鼻分泌物中EOS的百分比,鼻分泌物中EOS百分比可作为儿童AR治疗疗效的一个判定指标。
目的探討兒童變應性鼻炎(al ergic rhinitis,AR)患者在接受丙痠氟替卡鬆鼻噴霧劑治療前後鼻分泌物塗片中嗜痠性粒細胞(eosnophils,EOS)百分比的變化。方法收集由本院確診的持續性AR患兒(近1箇月內未接受任何糖皮質激素類藥物治療)60例為研究對象,均給予丙痠氟替卡鬆鼻噴霧劑治療,對其治療前及治療4w和8w後分彆檢查其鼻分泌物中EOS的百分比,觀察其變化。同時對AR患兒治療前及治療4w和8w後進行變應性鼻結膜炎癥狀視覺模擬評分判定療效。結果①治療前鼻分泌物中EOS百分比重度(躍0.50)的AR患兒44例,經丙痠氟替卡鬆鼻噴霧劑治療4w 31例鼻分泌物中EOS百分比下降,治療8w 42例鼻分泌物中EOS百分比下降,治療8w鼻分泌物中EOS百分比的下降率顯著高于治療4w,差異有統計學意義(字2=9.724,=0.003<0.05)；治療前鼻分泌物中EOS百分比中度(躍0.10-0.50)的AR患兒11例,經治療4w 6例鼻分泌物中EOS百分比下降,治療8w 10例鼻分泌物中EOS百分比下降,治療4w與治療8w鼻分泌物中EOS百分比下降率無統計學意義差異(字2=3.667,=0.149躍0.05)。②60例AR患兒經丙痠氟替卡鬆鼻噴霧劑治療4w的有效率為80.00%,治療8w的有效率為93.33%,治療8w的有效率高于治療4w的有效率,差異有統計學意義(字2=4.615,=0.032)。結論丙痠氟替卡鬆鼻噴霧劑治療兒童AR能迅速降低患兒鼻分泌物中EOS的百分比,鼻分泌物中EOS百分比可作為兒童AR治療療效的一箇判定指標。
목적탐토인동변응성비염(al ergic rhinitis,AR)환자재접수병산불체잡송비분무제치료전후비분비물도편중기산성립세포(eosnophils,EOS)백분비적변화。방법수집유본원학진적지속성AR환인(근1개월내미접수임하당피질격소류약물치료)60례위연구대상,균급여병산불체잡송비분무제치료,대기치료전급치료4w화8w후분별검사기비분비물중EOS적백분비,관찰기변화。동시대AR환인치료전급치료4w화8w후진행변응성비결막염증상시각모의평분판정료효。결과①치료전비분비물중EOS백분비중도(약0.50)적AR환인44례,경병산불체잡송비분무제치료4w 31례비분비물중EOS백분비하강,치료8w 42례비분비물중EOS백분비하강,치료8w비분비물중EOS백분비적하강솔현저고우치료4w,차이유통계학의의(자2=9.724,=0.003<0.05)；치료전비분비물중EOS백분비중도(약0.10-0.50)적AR환인11례,경치료4w 6례비분비물중EOS백분비하강,치료8w 10례비분비물중EOS백분비하강,치료4w여치료8w비분비물중EOS백분비하강솔무통계학의의차이(자2=3.667,=0.149약0.05)。②60례AR환인경병산불체잡송비분무제치료4w적유효솔위80.00%,치료8w적유효솔위93.33%,치료8w적유효솔고우치료4w적유효솔,차이유통계학의의(자2=4.615,=0.032)。결론병산불체잡송비분무제치료인동AR능신속강저환인비분비물중EOS적백분비,비분비물중EOS백분비가작위인동AR치료료효적일개판정지표。
Objective To explore the variation of Eosnophils in nasal secretion of children al ergic rhinitis before and after treatment with fluticason propionate nasal spray. Methods 60 children with al ergic rhinintis who had not received fluticason propionate nasal spray therapy in one month were selected in the study, and they were al gived fluticason propionate nasal spray. Eosnophils in nasal secretion was counted and the visual analogue scale of nasal conjunctivitis symptoms have been measureed before the treatment and 4 weeks and 8 weeks after the treatment. Results ①The rate of Eosnophils in nasal secretion of children al ergic rhinitis which was severe before treatment as 44 cases,31cases and 42 cases declined after 4 weeks and 8 weeks treatment , there was a significant dif erence between 4weeks and 8 weeks treatment (χ2=9.724,=0.003<0.05); The rate of Eosnophils in nasal secretion of children al ergic rhinitis which was moderate before treatment as 11 cases, 6cases and 10 cases declined after 4 weeks and 8 weeks treatment , there was no significant dif erence between 4weeks and 8 weeks treatment (χ2=3.667,=0.149>0.05).②The ef icient of children al ergic rhinitis who were treated with fluticason propionate nasal spray after 4 weeks was 80.00%and the ef icient of them after 8 weeks was 93.33%, compared the ef icient of them who were treated after 4 weeks and 8 weeks there was a significant dif erence (χ2=4.615,=0.032). Conclution Appliction of fluticason propionate nasal spray can decrease Eosnophils in nasal secretion of children al ergic rhinitis;Detection of Eosnophils in nasal secretion maybe an index for judging the therapeutic ef ect on children al ergic rhinitis.
