CAJ | 학술논문

目的：探讨曲尼司特治疗烧伤患者增生性瘢痕的临床疗效。方法选择医院收治产生增生性瘢痕的烧伤患者80例，随机分为对照组和观察组，各40例。两组患者均外用硅酮凝胶喷雾，观察组患者在此基础上口服曲尼司特胶囊，4周为1个疗程，均治疗2个疗程。结果治疗后，观察组总有效率为90．00％，显著高于对照组的75．00％（P＜0．05）；两组患者温哥华瘢痕量表(VSS )评分及瘢痕厚度、面积均较治疗前显著改善，且观察组改善程度更明显（P＜0．05）；两组患者疼痛及瘙痒的疼痛视觉模拟评分(VAS )均较治疗前显著改善，且观察组改善程度更明显（P＜0．05）。两组不良反应均较轻，发生率相当（P＞0．05）。结论曲尼司特治疗烧伤引起的增生性瘢痕，疗效显著，可有效减少瘢痕厚度、面积，缓解瘢痕引起的局部疼痛及瘙痒，且不良反应少、安全性好，值得临床推广。
목적：탐토곡니사특치료소상환자증생성반흔적림상료효。방법선택의원수치산생증생성반흔적소상환자80례，수궤분위대조조화관찰조，각40례。량조환자균외용규동응효분무，관찰조환자재차기출상구복곡니사특효낭，4주위1개료정，균치료2개료정。결과치료후，관찰조총유효솔위90．00％，현저고우대조조적75．00％（P＜0．05）；량조환자온가화반흔량표(VSS )평분급반흔후도、면적균교치료전현저개선，차관찰조개선정도경명현（P＜0．05）；량조환자동통급소양적동통시각모의평분(VAS )균교치료전현저개선，차관찰조개선정도경명현（P＜0．05）。량조불량반응균교경，발생솔상당（P＞0．05）。결론곡니사특치료소상인기적증생성반흔，료효현저，가유효감소반흔후도、면적，완해반흔인기적국부동통급소양，차불량반응소、안전성호，치득림상추엄。
Objective To investigate the clinical efficacy of tranilast for treating hypertrophic scars of burn patients.Methods 80 pa-tients with hypertrophic scars were randomly divided into control group and observation group,40 cases in each group.All patients were given topical silicone gel spray,on this basis the observation group was given an oral capsule tranilast,4 weeks was 1 course of treatment,all patients were treated for 2 courses.Results The total effective rate of the observation group was 90.00%,which was sig-nificantly better than 75.00% of the control group,the difference was statistically significant (P <0.05).After treatment,the VSS scores and scar thickness,area of the two groups of patients were significantly improved compared with before treatment,and the degree of improvement in the observation group was better than the control group,the differences were statistically significant (P <0.05). After treatment,the pain and itching VAS scores were significantly improved before treatment,and the degree of improvement in the observation group was better than the control group(P <0.05).Adverse reactions were mild in the two groups,and the incidence rates had no statistically significant difference(P >0.05).Conclusion Tranilast for the treatment of hypertrophic scars in burn patients can effectively reduce scar thickness and area and significantly relieve pain in patients with localized hypertrophic scars and itching,and has no significant adverse reactions,which is worthy of clinical promotion.