新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
Journal of Xinjiang Medical University
2015年
11期
1399-1402,1406
,共5页
李桂花%张震中%李沛珊%夏欢%杨新玲
李桂花%張震中%李沛珊%夏歡%楊新玲
리계화%장진중%리패산%하환%양신령
帕金森病%焦虑%抑郁
帕金森病%焦慮%抑鬱
파금삼병%초필%억욱
Parkinson′s disease%anxiety%depression
目的:探讨新疆维吾尔族与汉族帕金森病(Parkinson’s disease,PD)患者心理健康状态差异性及 PD患者抑郁的影响因素。方法选择130例 PD 患者(PD 组)(汉族80例,维族50例)和80例健康成人(正常对照组),通过完成基本情况调查表、临床症状评定量表(UPDRS)及 Hoehn-Yahn(H-Y)评分、广泛性焦虑量表-7项(GAD-7)和病人健康问卷抑郁量表-9项(PHQ-9),均进行空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-c)、低密度脂蛋白(LDL-c)、纤维蛋白(FIB)、尿酸(UA)、同型半胱氨酸(Hcy)及 C-反应蛋白(CRP)水平检测,比较维吾尔族和汉族 PD 患者各种评分及实验指标差异性,进一步分析 PD 患者抑郁的影响因素。结果维吾尔族 PD、汉族 PD 患者与正常对照组焦虑发生率分别为60.00%、56.25%和6.25%;3组抑郁发生率分别为48.00%、57.50%和7.50%。维吾尔族 PD 组、汉族 PD 组与正常对照组 GAD-7总评分分别为(11.16±5.89)分、(9.84±5.62)分、(3.75±2.94)分,3组 PHQ-9总评分分别为(9.60±5.64)分、(8.55±5.65)分、(3.50±1.99)分,维吾尔族 PD 组、汉族 PD 组分别与正常对照组在焦虑抑郁发生率及 GAD-7和 PHQ-9总评分方面比较差异有统计学意义(P <0.05),而维吾尔、汉族 PD 患者比较差异无统计学意义(P >0.05);相关性分析显示 PHQ-9总分与 H-Y分期、GAD-7呈正相关(r 分别为0.012和0.633,P <0.05),与 UA 呈负相关(r 为-0.299,P <0.05),多元回归分析显示 PHQ-9总分与 GAD-7和 UA 有相关性(β分别为0.631和0.012,P <0.05)。结论PD 患者焦虑及抑郁的发生率及严重程度明显高于正常人群,但维、汉族 PD 患者心理健康状态相比无明显差异,PD 患者的抑郁影响因素有 GAD-7和 UA,焦虑程度越重,UA 水平越低,PD 患者越易发生抑郁。
目的:探討新疆維吾爾族與漢族帕金森病(Parkinson’s disease,PD)患者心理健康狀態差異性及 PD患者抑鬱的影響因素。方法選擇130例 PD 患者(PD 組)(漢族80例,維族50例)和80例健康成人(正常對照組),通過完成基本情況調查錶、臨床癥狀評定量錶(UPDRS)及 Hoehn-Yahn(H-Y)評分、廣汎性焦慮量錶-7項(GAD-7)和病人健康問捲抑鬱量錶-9項(PHQ-9),均進行空腹血糖(FBG)、甘油三酯(TG)、總膽固醇(TC)、高密度脂蛋白(HDL-c)、低密度脂蛋白(LDL-c)、纖維蛋白(FIB)、尿痠(UA)、同型半胱氨痠(Hcy)及 C-反應蛋白(CRP)水平檢測,比較維吾爾族和漢族 PD 患者各種評分及實驗指標差異性,進一步分析 PD 患者抑鬱的影響因素。結果維吾爾族 PD、漢族 PD 患者與正常對照組焦慮髮生率分彆為60.00%、56.25%和6.25%;3組抑鬱髮生率分彆為48.00%、57.50%和7.50%。維吾爾族 PD 組、漢族 PD 組與正常對照組 GAD-7總評分分彆為(11.16±5.89)分、(9.84±5.62)分、(3.75±2.94)分,3組 PHQ-9總評分分彆為(9.60±5.64)分、(8.55±5.65)分、(3.50±1.99)分,維吾爾族 PD 組、漢族 PD 組分彆與正常對照組在焦慮抑鬱髮生率及 GAD-7和 PHQ-9總評分方麵比較差異有統計學意義(P <0.05),而維吾爾、漢族 PD 患者比較差異無統計學意義(P >0.05);相關性分析顯示 PHQ-9總分與 H-Y分期、GAD-7呈正相關(r 分彆為0.012和0.633,P <0.05),與 UA 呈負相關(r 為-0.299,P <0.05),多元迴歸分析顯示 PHQ-9總分與 GAD-7和 UA 有相關性(β分彆為0.631和0.012,P <0.05)。結論PD 患者焦慮及抑鬱的髮生率及嚴重程度明顯高于正常人群,但維、漢族 PD 患者心理健康狀態相比無明顯差異,PD 患者的抑鬱影響因素有 GAD-7和 UA,焦慮程度越重,UA 水平越低,PD 患者越易髮生抑鬱。
목적:탐토신강유오이족여한족파금삼병(Parkinson’s disease,PD)환자심리건강상태차이성급 PD환자억욱적영향인소。방법선택130례 PD 환자(PD 조)(한족80례,유족50례)화80례건강성인(정상대조조),통과완성기본정황조사표、림상증상평정량표(UPDRS)급 Hoehn-Yahn(H-Y)평분、엄범성초필량표-7항(GAD-7)화병인건강문권억욱량표-9항(PHQ-9),균진행공복혈당(FBG)、감유삼지(TG)、총담고순(TC)、고밀도지단백(HDL-c)、저밀도지단백(LDL-c)、섬유단백(FIB)、뇨산(UA)、동형반광안산(Hcy)급 C-반응단백(CRP)수평검측,비교유오이족화한족 PD 환자각충평분급실험지표차이성,진일보분석 PD 환자억욱적영향인소。결과유오이족 PD、한족 PD 환자여정상대조조초필발생솔분별위60.00%、56.25%화6.25%;3조억욱발생솔분별위48.00%、57.50%화7.50%。유오이족 PD 조、한족 PD 조여정상대조조 GAD-7총평분분별위(11.16±5.89)분、(9.84±5.62)분、(3.75±2.94)분,3조 PHQ-9총평분분별위(9.60±5.64)분、(8.55±5.65)분、(3.50±1.99)분,유오이족 PD 조、한족 PD 조분별여정상대조조재초필억욱발생솔급 GAD-7화 PHQ-9총평분방면비교차이유통계학의의(P <0.05),이유오이、한족 PD 환자비교차이무통계학의의(P >0.05);상관성분석현시 PHQ-9총분여 H-Y분기、GAD-7정정상관(r 분별위0.012화0.633,P <0.05),여 UA 정부상관(r 위-0.299,P <0.05),다원회귀분석현시 PHQ-9총분여 GAD-7화 UA 유상관성(β분별위0.631화0.012,P <0.05)。결론PD 환자초필급억욱적발생솔급엄중정도명현고우정상인군,단유、한족 PD 환자심리건강상태상비무명현차이,PD 환자적억욱영향인소유 GAD-7화 UA,초필정도월중,UA 수평월저,PD 환자월역발생억욱。
Objective To investigate the difference of mental health status in patients with Parkinson′s dis-ease (PD)of Uygur and Han in Xinjiang,and further to analyze the influence factors of the mental health status of depression in patients with PD.Methods 130 PD patients (80 cases of Han vs50 cases of Uygur) and and 80 cases of healthy adults (normal control group),were enrolled into the study.All of the partici-pants were asked to finish the questionnaires,such as the basic information,the Unified Parkinson′s dis-ease Rating Scale (UPDRS)and Hoehn & Yahn (H-Y)scale,the generalized anxiety scale-7 (GAD-7), the patient health questionnaire depression scale-9 (PHQ-9),and to be taken fasting Venous blood sample for detecting glucose (FBG),triglyceride (TG),total cholesterol (TC),high-density lipoprotein choles-terol (HDLc),low density lipoprotein cholesterol (LDLc),uric acid (UA),homocysteine (Hcy),fibrinogen (Fib)and Creactive protein (CRP)to further analyze the factors of depression in patients withPD.Results The rates of anxiety respectively were 60.0%,56.25%,6.25% in Han PD,Uygur PD andnormal group .The rate of depression respectively were 48%,57.5%,7.5% in those three groups.The total scores of GAD7 in Han PD,Uygur PD and normal group were respectively (11.16±5.89),(9.84±5.62)and (3.75±2.94).The total scores of PHQ9 were respectively (9.60±5.64),(8.55±5.65)and(3.50±1.99)where there were significant differences between Uygur PD,Han PD and normal controlgroup,however no significant difference between Uygur and Han PD.Correlation analysis showed that thetotal score of PHQ9 were positively correlated with HY scale and GAD7 scores (β=0.012 and 0.633,P<0.05),and negatively correlated with UA (beta=-0.299,P <0.05).Multiple regression analysisshowed that the total score of PHQ9 was associated with GAD7 scores and UA (β= 0.631and 0.012,P<0.05).Conclusion The rate of incidence of anxiety and depression and severity in patients with PD werehigher than that of the general population.There was no significant difference in incidence of anxiety anddepression in patients between Uygur and Han PD,the factors of the mental health status of depression inpatients with PD were GAD7 and UA.The heavier anxiety degree,the lower the level of UA,the morebeing prone to depression in patients with PD.