CAJ | 학술논문

目的：观察加用麝穿脑立通颗粒治疗成人化脓性脑膜炎的临床疗效，并探讨护理方案。方法选择医院收治的化脓性脑膜炎患者100例，随机分为治疗组和对照组，各50例。对照组患者采用常规治疗，给予甘露醇、抗生素、激素等，治疗组患者在对照组治疗基础之上加用麝穿脑立通颗粒，治疗7d。观察患者治疗前后睁眼反应、语言反应、肢体活动、意识、体温等基本情况的改善情况，检测患者的全血白细胞数（B-WBC）、脑脊液白细胞数（CSF-WBC），记录不良反应。结果治疗后，治疗组总有效率为96．00％，高于对照组的88．00％（P＜0．05）；两组患者治疗后，格拉斯哥昏迷评分量表(GCS )评分均提高（P＜0．05），且治疗组提高更显著（P＜0．05）；两组患者B-WBC，CSF-WBC均明显下降（P＜0．05），且治疗组患者下降更显著（P＜0．05）；两组患者均未出现严重肝肾功能损伤及严重过敏症状。结论在常规治疗基础上加用麝穿脑立通颗粒治疗成人化脓性脑膜炎，临床疗效好，能缓解患者的意识障碍，降低中枢神经系统及外周血中炎性介质的释放，安全性好。配合适当的护理，能进一步提高临床疗效，值得临床推广。
목적：관찰가용사천뇌립통과립치료성인화농성뇌막염적림상료효，병탐토호리방안。방법선택의원수치적화농성뇌막염환자100례，수궤분위치료조화대조조，각50례。대조조환자채용상규치료，급여감로순、항생소、격소등，치료조환자재대조조치료기출지상가용사천뇌립통과립，치료7d。관찰환자치료전후정안반응、어언반응、지체활동、의식、체온등기본정황적개선정황，검측환자적전혈백세포수（B-WBC）、뇌척액백세포수（CSF-WBC），기록불량반응。결과치료후，치료조총유효솔위96．00％，고우대조조적88．00％（P＜0．05）；량조환자치료후，격랍사가혼미평분량표(GCS )평분균제고（P＜0．05），차치료조제고경현저（P＜0．05）；량조환자B-WBC，CSF-WBC균명현하강（P＜0．05），차치료조환자하강경현저（P＜0．05）；량조환자균미출현엄중간신공능손상급엄중과민증상。결론재상규치료기출상가용사천뇌립통과립치료성인화농성뇌막염，림상료효호，능완해환자적의식장애，강저중추신경계통급외주혈중염성개질적석방，안전성호。배합괄당적호리，능진일보제고림상료효，치득림상추엄。
Objective To investigate the clinical efficacy of Shechuannaolitong Granules in treating adult intracranial suppurative infec-tions and its nursing plan.Methods 100 cases of adult patients with suppurative meningitis infection in the hospital were randomly di-vided into the treatment group and the control group.The control group was treated with conventional therapy,giving the mannitol,an-tibiotics,hormones and other treatments,and the observation group was given Shechuannaolitong Granules on the basis of the control group.The treatment lasted for 7 d.The patient′s consciousness,body temperature were observed and recorded,and whole blood leukocyte count(B-WBC) and cerebrospinal fluid white blood cell count(CSF-WBC) were detected.The adverse reactions were recorded. Results The total effective rate of the treatment group was 96.00%,which was significantly higher than 88.00% of the control group (P <0.05);the GCS scores of the two groups were improved than before treatment(P <0.05),and the treatment group improved better (P <0.05);the B-WBC,CSF-WBC of the two groups were declined(P <0.05),and the treatment group declined more significantly (P <0.05).No adverse reactions occurred in the two groups.Conclusion Shechuannaolitong Granules in treating adult patients with in-tracranial suppurative meningitis treatment can quickly improve the efficacy,unconsciousness,reduce the release of the central nervous system and peripheral blood inflammatory mediators,has good safety,and with proper nursing it can further improve the clinical efficacy, and is worthy of clinical promotion.