CAJ | 학술논문

目的：观察中西医结合卒中单元模式对维吾尔、汉族急性缺血性脑卒中患者治疗前后血流变及血浆的凝血酶激活的纤溶抑制物（TAFI）、纤维蛋白原（FIB）、D-二聚体（D-D）含量变化的影响。方法选择维吾尔、汉族急性缺血性脑卒中患者848例，经中西医结合卒中单元模式治疗，检测维吾尔、汉族急性脑卒中患者在入院时及1个疗程后的血流变各项指标及血浆的 TAFI、FIB、D-D 含量的变化。结果维吾尔、汉族急性脑卒中患者治疗前与治疗后的美国国立卫生研究院卒中量表（NIHSS）评分比较差异均有统计学意义（P ＜0．01），维吾尔、汉族患者恢复情况比较差异有统计学意义（P ＜0．01）；维吾尔族患者治疗后血流变的各项指标及 TAFI 含量与治疗前比较差异均有统计学意义（P ＜0．01），汉族患者治疗前与治疗后比较，血流变指标全血黏度5、全血黏度200、血浆黏度、血沉以及 TAFI 差异均有统计学意义（P ＜0．01），D-D 含量比较差异无统计学意义；维吾尔、汉族患者治疗前与治疗后全血黏度1和全血黏度30差值差异有统计学意义（P ＜0．05）。结论中西医结合卒中单元模式治疗维吾尔、汉族急性脑卒中患者都具有很好的疗效，而且维吾尔族患者效果更佳。
목적：관찰중서의결합졸중단원모식대유오이、한족급성결혈성뇌졸중환자치료전후혈류변급혈장적응혈매격활적섬용억제물（TAFI）、섬유단백원（FIB）、D-이취체（D-D）함량변화적영향。방법선택유오이、한족급성결혈성뇌졸중환자848례，경중서의결합졸중단원모식치료，검측유오이、한족급성뇌졸중환자재입원시급1개료정후적혈류변각항지표급혈장적 TAFI、FIB、D-D 함량적변화。결과유오이、한족급성뇌졸중환자치료전여치료후적미국국립위생연구원졸중량표（NIHSS）평분비교차이균유통계학의의（P ＜0．01），유오이、한족환자회복정황비교차이유통계학의의（P ＜0．01）；유오이족환자치료후혈류변적각항지표급 TAFI 함량여치료전비교차이균유통계학의의（P ＜0．01），한족환자치료전여치료후비교，혈류변지표전혈점도5、전혈점도200、혈장점도、혈침이급 TAFI 차이균유통계학의의（P ＜0．01），D-D 함량비교차이무통계학의의；유오이、한족환자치료전여치료후전혈점도1화전혈점도30차치차이유통계학의의（P ＜0．05）。결론중서의결합졸중단원모식치료유오이、한족급성뇌졸중환자도구유흔호적료효，이차유오이족환자효과경가。
Objective To observe the influences of Integrative stroke unit model (ISUM)in treatment of a-cute stroke patients of Uygur and Han ethnic before and after hemorheology indexes and plasma thrombin activatable fibrinolysis inhibitor (TAFI),fibrinogen (FIB),D-dimer content.Methods Uygur and Han patients with acute ischemic stroke were selected to conduct treatment with the ISUM.Hemorheology in-dexes and TAFI,FIB and D-dimer contents were measured before and after inpatient for 1 course of treat-ment.Results The NIHSS scores of Uygur and Han patients with acute stroke before and after treatment were significantly different (P < 0.01 ).And the recovery status of two ethnic patients was significant difference (P <0.01);the hemorheology indexes and TAFI levels of Uygur and Han patients before and after treatment were significantly different (P <0.01);the differences of the whole blood viscosity and whole blood viscosity 30 differences of two groups before and after treatment were significant difference (P <0.05).Conclusion ISUM treatment for Uygur and Han acute stroke patients had a good effect,espe-cially better for Uygur patients.