医学信息
醫學信息
의학신식
Medical Information
2015年
43期
120-120
,共1页
高灵%孟照辉%王琦%曹原%郭磊%吴春华
高靈%孟照輝%王琦%曹原%郭磊%吳春華
고령%맹조휘%왕기%조원%곽뢰%오춘화
冠心病%基质金属蛋白酶-12%酶联免疫吸附法
冠心病%基質金屬蛋白酶-12%酶聯免疫吸附法
관심병%기질금속단백매-12%매련면역흡부법
Coronary heart disease%MMP-12%ELISA
目的探讨冠心病患者血清中MMP-12的表达情况。方法选取90例行冠状动脉造影的患者,采用ELISA检测其血清中MMP-12的含量。根据冠心病临床分型分为稳定性心绞痛、急性冠脉综合征和冠心病合并2型糖尿病,以CA正常为对照。结果 ACS及CHD+DM组血清MMP-12水平高于CA组及SAP组(<0.05)。结论冠心病患者血清中MMP-12水平增高与斑块的不稳定有关;2型糖尿病可增加冠心病患者血清MMP-12的水平。
目的探討冠心病患者血清中MMP-12的錶達情況。方法選取90例行冠狀動脈造影的患者,採用ELISA檢測其血清中MMP-12的含量。根據冠心病臨床分型分為穩定性心絞痛、急性冠脈綜閤徵和冠心病閤併2型糖尿病,以CA正常為對照。結果 ACS及CHD+DM組血清MMP-12水平高于CA組及SAP組(<0.05)。結論冠心病患者血清中MMP-12水平增高與斑塊的不穩定有關;2型糖尿病可增加冠心病患者血清MMP-12的水平。
목적탐토관심병환자혈청중MMP-12적표체정황。방법선취90례행관상동맥조영적환자,채용ELISA검측기혈청중MMP-12적함량。근거관심병림상분형분위은정성심교통、급성관맥종합정화관심병합병2형당뇨병,이CA정상위대조。결과 ACS급CHD+DM조혈청MMP-12수평고우CA조급SAP조(<0.05)。결론관심병환자혈청중MMP-12수평증고여반괴적불은정유관;2형당뇨병가증가관심병환자혈청MMP-12적수평。
Objective To explore the serum MMP-12 in patients with CHD.Methods Serum samples were obtained from 90 patients,having normal coronary arteries as a control group.The level of MMP-12 was analyzed by ELISA.According to clinical classification were divided into SAP,ACS and CHD+DM.Results Serum MMP-12 were markedly increased in ACS and CHD+DM group compared with control and SAP group( <0.05).Conclusion The high MMP-12 with CHD was suggesting that it maybe related to the stability of coronary plaque.Type 2 diabetes significantly increased the levels of MMP-12 from patients with CHD.