CAJ | 학술논문

目的：观察柴郁汤、芍甘汤和痛泻要方在α-异硫氰酸萘酯（ANIT）造成的大鼠肝内胆汁淤积模型上的利胆作用。方法将健康Wistar大鼠96只分为12组，即正常对照组，胆汁淤积模型组（简称模型组），柴郁汤低、中、高剂量组，芍甘汤低、中、高剂量组，痛泻要方低、中、高剂量组和熊去氧胆酸组，各8只。第1天对大鼠进行胆管插管；第2天早上正常对照组灌胃食用豆油，其余组灌胃4％ANIT；第4天早上各组均收集1h胆汁，然后除正常对照组灌胃蒸馏水外，其余各组灌胃相应药物，晚上再灌胃1次，灌胃1h后收集1h胆汁；第5天早晚各灌胃1次，晚上灌胃1h 后收集1h 胆汁。结果与给药前比较，3种中药复方给药后第2天胆汁均明显增多（P＜0．05）。结论柴郁汤、芍甘汤和痛泻要方对药物所致大鼠胆汁淤积皆有利胆作用。
목적：관찰시욱탕、작감탕화통사요방재α-이류청산내지（ANIT）조성적대서간내담즙어적모형상적리담작용。방법장건강Wistar대서96지분위12조，즉정상대조조，담즙어적모형조（간칭모형조），시욱탕저、중、고제량조，작감탕저、중、고제량조，통사요방저、중、고제량조화웅거양담산조，각8지。제1천대대서진행담관삽관；제2천조상정상대조조관위식용두유，기여조관위4％ANIT；제4천조상각조균수집1h담즙，연후제정상대조조관위증류수외，기여각조관위상응약물，만상재관위1차，관위1h후수집1h담즙；제5천조만각관위1차，만상관위1h 후수집1h 담즙。결과여급약전비교，3충중약복방급약후제2천담즙균명현증다（P＜0．05）。결론시욱탕、작감탕화통사요방대약물소치대서담즙어적개유리담작용。
Objective To observe the influence of Chaiyu Decoction,Shaogan Decoction and Tongxie prescription on ANIT-induced cholestasic rats.Methods 96 healthy Wistar rats were divided into 12 groups,namely normal control group,model group,Chaiyu Decoc-tion groups of low,middle and high dose,Shaogan Decoction groups of low,middle and high dose,and Ursodeoxycholic acid tablet group.On day 1,rats were treated with bile duct intubation.On day 2,rats of normal control group were administered bean oil,and oth-er groups were treated with 4% ANIT.On day 4,each group was administered corresponding drug after being colleceted bile for 1 hour in the morning,and was treated accordingly again at night,then collected bile for 1 hour.On day 5,treatment was same as day 4 ex-cept rats were not collected bile in the morning.Results After treated with three Chinese traditional prescriptions bile of rats on day 2 was remarkably increased compared with group of non-treatment.Conclusion 3 traditional Chinese prescriptions Chaiyu Decoction, Shaogan Decoction,Tongxie prescription have cholagogic actions on ANIT-induced cholestasic rats.