CAJ | 학술논문

目的：通过观察盐酸氨溴索综合治疗新生儿呼吸窘迫综合征临床疗效及安全性，从而可为临床患儿规范化治疗提供参考。方法：按照随机数字表法将我院2013年5月～2014年5月期间所收治的96例新生儿呼吸窘迫综合征分组为对照组与治疗组，各48例。对照组采用固尔苏治疗；治疗组于对照组治疗基础上加用盐酸氨溴索治疗。比较两组患儿机械通气参数、治疗前后血气分析、氧疗时间、住院时间及并发症。结果：两组患儿治疗后各项血气分析指标较治疗均明显改善，但治疗组改善较对照组显著，具有统计学意义；治疗组患儿治疗后呼气末正压和吸气峰压及吸入氧浓度均明显优于对照组。治疗组氧疗时间及住院时间明显短于对照组[（58.5±12.6）h、（14.1±5.9）天] vs [（91.7±17.5）h、（19.8±8.2）天]；治疗组并发症者2例，并发症率为4.17%明显低于对照组8例，占16.67%。结论：临床应用盐酸氨溴索联合固尔苏治疗新生儿呼吸窘迫综合征可有效改善其机械通气及血气状况，同时还可减少并发症发生，从而缩短其氧疗时间及住院时间。
목적：통과관찰염산안추색종합치료신생인호흡군박종합정림상료효급안전성，종이가위림상환인규범화치료제공삼고。방법：안조수궤수자표법장아원2013년5월～2014년5월기간소수치적96례신생인호흡군박종합정분조위대조조여치료조，각48례。대조조채용고이소치료；치료조우대조조치료기출상가용염산안추색치료。비교량조환인궤계통기삼수、치료전후혈기분석、양료시간、주원시간급병발증。결과：량조환인치료후각항혈기분석지표교치료균명현개선，단치료조개선교대조조현저，구유통계학의의；치료조환인치료후호기말정압화흡기봉압급흡입양농도균명현우우대조조。치료조양료시간급주원시간명현단우대조조[（58.5±12.6）h、（14.1±5.9）천] vs [（91.7±17.5）h、（19.8±8.2）천]；치료조병발증자2례，병발증솔위4.17%명현저우대조조8례，점16.67%。결론：림상응용염산안추색연합고이소치료신생인호흡군박종합정가유효개선기궤계통기급혈기상황，동시환가감소병발증발생，종이축단기양료시간급주원시간。
objectiveBy observing ambroxol comprehensive treatment of neonatal respiratory distress syndrome, the clini-cal efficacy and safety, which can provide a reference for the clinical treatment of children with stand ardization. Methods Ac-cording to a random number table are admitted to our hospital in May 2013 - May 2014 period 96 cases of neonatal respiratory distress syndrome group was the control group and the treatment group, 48 cases each. The control group was Curosurf treat-ment; treatment group based on the use ambroxol treatment in the control group. Comparison of the two groups of children with mechanical ventilation parameters, blood gas analysis before and after treatment, oxygen therapy, hospital stay and complica-tions. Results Two groups of children after treatment of the blood gas analysis were significantly improved compared with the treatment, but the treatment group improved significantly compared with the control group, with statistical significance; children after treatment, PEEP and peak inspiratory pressure and inspired oxygen concentration was significantly better than the control group. Oxygen therapy and hospital treatment group was significantly shorter than the control group [(58.5±12.6) h, (14.1± 5.9) days] vs [(91.7±17.5) h, (19.8±8.2) days]; treatment group 2 cases of complications, complication rate was 4.17% in the control group was significantly lower than the 8 cases, accounting for 16.67%. ConclusionClinical application of ambroxol hy-drochloride combined Curosurf treatment of neonatal respiratory distress syndrome can effectively improve its mechanical ven-tilation and blood gas status, but can also reduce complications occur, reducing its oxygen therapy and hospitalization time.