CAJ | 학술논문

目的探讨IL-8、IL-18在种植体周围炎龈沟液( GCF)中的表达及意义. 方法选择2011年1月~2013年12月期间40例种植体周围炎患者为研究对象. 另选择健康种植体患者40例. 选择健康人群50例为健康对照组. 统计3组探诊深度(PD)、龈沟出血指数(SBI)、IL-8、IL-18质量浓度,并对GCF中IL-8、IL-18质量浓度与性别、年龄、PD、SBI进行相关性分析. 结果种植体周围炎组PD、SBI、GCF均高于健康种植体组和对照组,差异有统计学意义(P<0.01);但健康种植体组和对照组PD、SBI、GCF差异无统计学意义(P>0.05);种植体周围炎组IL-8、IL-18水平高于健康种植体组和对照组,差异有统计学意义(P<0.01),健康种植体组IL-8、IL-18水平高于对照组,差异有统计学意义(P<0.01);不同性别种植体周围炎患者GCF中IL-8、IL-18水平比较,差异无统计学意义(P>0.05);≥60岁组IL-8、IL-18水平高于<60岁组和对照组,差异有统计学意义(P<0.01),<60岁组IL-8、IL-18水平高于对照组,差异有统计学意义(P<0.01);GCF 与PD、SBI、IL-8、IL-18呈正相关(P<0.05);IL-8、IL-18与年龄、PD、SBI呈正相关(P<0.05);IL-8和IL-18之间呈正相关(P<0.05). 结论 IL-8、IL-18在种植体周围炎患者GCF中呈高表达;GCF中IL-8、IL-18的特异性表达与种植体周围炎密切相关.
목적 탐토IL-8、IL-18재충식체주위염간구액( GCF)중적표체급의의. 방법 선택2011년1월~2013년12월기간40례충식체주위염환자위연구대상. 령선택건강충식체환자40례. 선택건강인군50례위건강대조조. 통계3조탐진심도(PD)、간구출혈지수(SBI)、IL-8、IL-18질량농도,병대GCF중IL-8、IL-18질량농도여성별、년령、PD、SBI진행상관성분석. 결과 충식체주위염조PD、SBI、GCF균고우건강충식체조화대조조,차이유통계학의의(P<0.01);단건강충식체조화대조조PD、SBI、GCF차이무통계학의의(P>0.05);충식체주위염조IL-8、IL-18수평고우건강충식체조화대조조,차이유통계학의의(P<0.01),건강충식체조IL-8、IL-18수평고우대조조,차이유통계학의의(P<0.01);불동성별충식체주위염환자GCF중IL-8、IL-18수평비교,차이무통계학의의(P>0.05);≥60세조IL-8、IL-18수평고우<60세조화대조조,차이유통계학의의(P<0.01),<60세조IL-8、IL-18수평고우대조조,차이유통계학의의(P<0.01);GCF 여PD、SBI、IL-8、IL-18정정상관(P<0.05);IL-8、IL-18여년령、PD、SBI정정상관(P<0.05);IL-8화IL-18지간정정상관(P<0.05). 결론 IL-8、IL-18재충식체주위염환자GCF중정고표체;GCF중IL-8、IL-18적특이성표체여충식체주위염밀절상관.
Objective To study IL -8,IL-18 expression in peri -implantitis gingival crevicular fluid and clinical significance . Methods Between January 2011 and December 2013, 40 patients with peri-implantitis were selected as the research object .40 cases of healthy implant patients were selected .50 cases of healthy people healthy were selected as the controls .The probing depth ( PD) , sulcus bleeding index (SBI), GCF IL-8,IL-18 mass concentration in the three groups were tested , and correlation analysis between IL -8,IL-18 mass concentration in GCF and gender , age, PD and SBI were made.Results PD and SBI, GCF in peri-implant group were higher than healthy implant group and the control group , and the difference was statistically significant (P<0.01).But the PD and SBI, GCF of healthy implant group and the control group B had no obvious difference (P>0.05);IL-8,IL-18 in peri-implant group was higher than healthy implant group and the control group , and the difference was statistically significant (P<0.01).IL-8,IL-18 levels in healthy implant group was higher than the control group , and difference was statistically significant (P<0.01).Peri-implant patients with different gender in GCF IL -8,IL-18 levels, and there was no statistically significant difference (P>0.05).IL-8,IL-18 levels of patients whose ages were 60 or higher in peri-implant group were higher than the <60 years old group and the control group ,and the difference was statistically significant (P<0.01).IL-8,IL-18 levels in the <60 years old group were higher than the control group , and difference was statistically significant (P<0.01).The GCF was positively correlated with PD, SBI, IL-8, IL-18 (P<0.05). IL-8, IL-18 was positively correlated with age , PD, SBI (P<0.05).There was a positive correlation between IL -8 and IL-18 (P<0.05).Conclusion IL-8,IL-18 show high expression in GCF in peri -implantitis.The specific expressions of IL -8,IL-18 in GCF are closely related to peri -implantitis.