CAJ | 학술논문

目的：应用磁共振弥散张量成像(diffusion tensor imaging，DTI)研究并鉴别阿尔茨海默病与轻度认知障碍患者的脑白质损伤情况。方法对于45例阿尔茨海默病患者(AD组)和45例轻度认知障碍患者(MCI组)进行脑部DTI扫描，测量部分区域各项异性分数值(FA)和平均弥散率(mean diffusivity，MD)并进行比较。结果与MCI组相比，AD组两侧海马旁回、两侧下额枕束、两侧下纵束和两侧后扣带回的FA值均显著降低，P<0.05。与MCI组相比，AD组两侧海马旁回、两侧下额枕束、两侧下纵束和两侧后扣带回的MD值均显著升高，P<0.05。结论 DTI技术可以灵敏检测出AD患者与MCI患者的脑白质结构差异，从而可作为MCI与AD的鉴别指标。
목적：응용자공진미산장량성상(diffusion tensor imaging，DTI)연구병감별아이자해묵병여경도인지장애환자적뇌백질손상정황。방법대우45례아이자해묵병환자(AD조)화45례경도인지장애환자(MCI조)진행뇌부DTI소묘，측량부분구역각항이성분수치(FA)화평균미산솔(mean diffusivity，MD)병진행비교。결과여MCI조상비，AD조량측해마방회、량측하액침속、량측하종속화량측후구대회적FA치균현저강저，P<0.05。여MCI조상비，AD조량측해마방회、량측하액침속、량측하종속화량측후구대회적MD치균현저승고，P<0.05。결론 DTI기술가이령민검측출AD환자여MCI환자적뇌백질결구차이，종이가작위MCI여AD적감별지표。
Objective to application of magnetic resonance diffusion tensor imaging (coursing together tensor imaging, DTI) research and identification of alzheimer's disease and mild cognitive impairment in patients with cerebral white matter damage.Methods for 45 cases of alzheimer's disease (AD) and 45 cases of patients with mild cognitive impairment (MCI) in brain DTI scan, measure the area of the opposite sex (FA) and an average score value dispersion rate (mean diffusivity, MD) and the comparison.Results compared with MCI group, AD groups on both sides of the parahippocampal gyrus, sides on both sides of the pillow, on both sides of the longitudinal beam and cingulate FA values were significantly lower after, P<0.05). Compared with MCI group, AD groups on both sides of the parahippocampal gyrus, sides on both sides of the pillow, on both sides of the longitudinal beam and the cingulate cortex, MD, of the rise, P<0.05).Conclusions DTI technology can be sensitive to detect the AD patients with MCI patients of cerebral white matter structure difference, which can be used for identification of MCI and AD.