湖南师范大学学报（医学版）
湖南師範大學學報（醫學版）
호남사범대학학보（의학판）
Journal of Hunan Normal University (Medical Science)
2015年
4期
34-37
,共4页
任清泉%杨扬%张孟斌%王启
任清泉%楊颺%張孟斌%王啟
임청천%양양%장맹빈%왕계
食管鳞癌%根治术%预后%生存分析%Cox 回归分析
食管鱗癌%根治術%預後%生存分析%Cox 迴歸分析
식관린암%근치술%예후%생존분석%Cox 회귀분석
esophageal squamous cell carcinoma%radical resection%prognosis%survival analysis%Cox regression analysis
目的：观察和分析食管癌根治术患者预后的相关研究。方法：选取180例行根治术的食管鳞癌患者作为研究对象，对其性别、年龄、体质指数、病变部位、肿瘤长度、分化程度、外侵程度、远处转移、术后病理 TNM 分期、淋巴结转移情况、手术方式、残端受侵、吻合口瘘、术后感染等情况进行记录和比较。对患者进行术后随访，对其总生存期（OS）进行分析和比较。结果：具有不同的病变部位、肿瘤长度、分化程度、外侵程度、TNM 分期、淋巴结转移、术后感染的患者的 OS 中位数估计值的差异均有统计学意义，Cox 多元回归分析结果显示，食管癌根治术患者的预后与肿瘤的分化程度（RR=0.582）、侵润程度（RR=1.453）、肿瘤长度（RR=1.337）、淋巴结转移（RR=2.257）及患者术后感染（RR=1.637）具有相关性。结论：食管癌根治术患者的预后与多种因素具有相关性，临床医生应准确识别高危因素并采用及时有效的干预措施，从而达到改善患者预后的目标。
目的：觀察和分析食管癌根治術患者預後的相關研究。方法：選取180例行根治術的食管鱗癌患者作為研究對象，對其性彆、年齡、體質指數、病變部位、腫瘤長度、分化程度、外侵程度、遠處轉移、術後病理 TNM 分期、淋巴結轉移情況、手術方式、殘耑受侵、吻閤口瘺、術後感染等情況進行記錄和比較。對患者進行術後隨訪，對其總生存期（OS）進行分析和比較。結果：具有不同的病變部位、腫瘤長度、分化程度、外侵程度、TNM 分期、淋巴結轉移、術後感染的患者的 OS 中位數估計值的差異均有統計學意義，Cox 多元迴歸分析結果顯示，食管癌根治術患者的預後與腫瘤的分化程度（RR=0.582）、侵潤程度（RR=1.453）、腫瘤長度（RR=1.337）、淋巴結轉移（RR=2.257）及患者術後感染（RR=1.637）具有相關性。結論：食管癌根治術患者的預後與多種因素具有相關性，臨床醫生應準確識彆高危因素併採用及時有效的榦預措施，從而達到改善患者預後的目標。
목적：관찰화분석식관암근치술환자예후적상관연구。방법：선취180례행근치술적식관린암환자작위연구대상，대기성별、년령、체질지수、병변부위、종류장도、분화정도、외침정도、원처전이、술후병리 TNM 분기、림파결전이정황、수술방식、잔단수침、문합구루、술후감염등정황진행기록화비교。대환자진행술후수방，대기총생존기（OS）진행분석화비교。결과：구유불동적병변부위、종류장도、분화정도、외침정도、TNM 분기、림파결전이、술후감염적환자적 OS 중위수고계치적차이균유통계학의의，Cox 다원회귀분석결과현시，식관암근치술환자적예후여종류적분화정도（RR=0.582）、침윤정도（RR=1.453）、종류장도（RR=1.337）、림파결전이（RR=2.257）급환자술후감염（RR=1.637）구유상관성。결론：식관암근치술환자적예후여다충인소구유상관성，림상의생응준학식별고위인소병채용급시유효적간예조시，종이체도개선환자예후적목표。
ObjectiveTo observe and analyze the related factors of the prognosis of patients with esophageal carcinoma after radical resection. Methods180 patients with esophageal squamous cell carcinoma treated with radical resection were se-lected as the research objects. The gender, the age, the body mass index, the location of the lesion, the length of tumor, the de-gree of differentiation, the degree of invasion, the faraway metastasis, the postoperative pathological TNM staging, the metastasis to lymph node, the operation mode, the stump invaded, the anastomotic fistula, the postoperative infection of the patients were recorded and compared. The patients were followed up after surgery, the overall survival (OS) were analyzed and compared. Results The differences of OS of the patients with different location of the lesion, length of tumor, degree of differentiation, de-gree of invasion, postoperative pathological TNM staging, metastasis to lymph node, postoperative infection were statistically significant. Cox regression analysis showed the prognosis of patients with esophageal carcinoma treated with radical resection was correlated with the degree of differentiation (RR=0.582), the degree of invasion (RR=1.453), the length of tumor (RR=1.337), the metastasis to lymph node (RR=2.257) and the postoperative infection (RR=1.637). Conclusion The prognosis of patients with esophageal cancer treated with radical resection is associated with many factors. The clinicians should accurately identify the risk factors and employ timely and effective intervention measures, so as to achieve the goal of improve the prognosis of the patients.
