医学研究杂志
醫學研究雜誌
의학연구잡지
Journal of Medical Research
2015年
10期
86-89
,共4页
吴柳青%李宇%杨宗勇%林峥%徐时好
吳柳青%李宇%楊宗勇%林崢%徐時好
오류청%리우%양종용%림쟁%서시호
右美托咪定%高血压%插管%心血管反应%非劣性分析
右美託咪定%高血壓%插管%心血管反應%非劣性分析
우미탁미정%고혈압%삽관%심혈관반응%비렬성분석
Dexmedetomidine%Hypertension%Intubation%Cardiovascular response%Noninferiority
目的 探讨小剂量右美托咪定抑制非老年高血压患者插管反应的疗效,分析其最佳有效剂量及安全性,确定最佳有效剂量. 方法 选取笔者医院2013年1月~2014年8月非老年高血压患者100例,择期行手术全身麻醉气管插管,随机分为对照组和试验组,各50例,试验组给予右美托咪定0.6μg/kg,对照组给予右美托咪定1.0μg/kg. 观察记录两组基础值15min (T0)、诱导前即刻(T1)、插管前即刻(T2)、插管后1min(T3)的平均动脉压(MAP)、呼吸(HR)、心率(RR)、血氧饱和度(SpO2)、收缩压(SBP)、舒张压(DBP),进行非劣效性分析并观察不良反应. 结果 两组患者在麻醉插管后HR、RR、SpO2、SBP和DBP均有降低,对照组和试验组患者插管后1min MAP的变化率分别为15.3%和15.1%. 试验组患者不良反应结果为4.00%(2/50),显著低于对照组14.00%(7/50),( P<0.05). 结论 0.6μg/kg 右美托咪定抑制非老年高血压患者插管反应的疗效不低于1.0μg/kg,并且可以降低不良反应的发生.
目的 探討小劑量右美託咪定抑製非老年高血壓患者插管反應的療效,分析其最佳有效劑量及安全性,確定最佳有效劑量. 方法 選取筆者醫院2013年1月~2014年8月非老年高血壓患者100例,擇期行手術全身痳醉氣管插管,隨機分為對照組和試驗組,各50例,試驗組給予右美託咪定0.6μg/kg,對照組給予右美託咪定1.0μg/kg. 觀察記錄兩組基礎值15min (T0)、誘導前即刻(T1)、插管前即刻(T2)、插管後1min(T3)的平均動脈壓(MAP)、呼吸(HR)、心率(RR)、血氧飽和度(SpO2)、收縮壓(SBP)、舒張壓(DBP),進行非劣效性分析併觀察不良反應. 結果 兩組患者在痳醉插管後HR、RR、SpO2、SBP和DBP均有降低,對照組和試驗組患者插管後1min MAP的變化率分彆為15.3%和15.1%. 試驗組患者不良反應結果為4.00%(2/50),顯著低于對照組14.00%(7/50),( P<0.05). 結論 0.6μg/kg 右美託咪定抑製非老年高血壓患者插管反應的療效不低于1.0μg/kg,併且可以降低不良反應的髮生.
목적 탐토소제량우미탁미정억제비노년고혈압환자삽관반응적료효,분석기최가유효제량급안전성,학정최가유효제량. 방법 선취필자의원2013년1월~2014년8월비노년고혈압환자100례,택기행수술전신마취기관삽관,수궤분위대조조화시험조,각50례,시험조급여우미탁미정0.6μg/kg,대조조급여우미탁미정1.0μg/kg. 관찰기록량조기출치15min (T0)、유도전즉각(T1)、삽관전즉각(T2)、삽관후1min(T3)적평균동맥압(MAP)、호흡(HR)、심솔(RR)、혈양포화도(SpO2)、수축압(SBP)、서장압(DBP),진행비렬효성분석병관찰불량반응. 결과 량조환자재마취삽관후HR、RR、SpO2、SBP화DBP균유강저,대조조화시험조환자삽관후1min MAP적변화솔분별위15.3%화15.1%. 시험조환자불량반응결과위4.00%(2/50),현저저우대조조14.00%(7/50),( P<0.05). 결론 0.6μg/kg 우미탁미정억제비노년고혈압환자삽관반응적료효불저우1.0μg/kg,병차가이강저불량반응적발생.
Objective To explore noninferiority of low dose of dexmedetomidine on inhibiting anesthesia intubation -induced cardio-vascular response in non -senile hypertension patients .We analyzed the best effective dose and safety , and determined the best effective dose.Methods One hundred non-senile hypertension patients with elective surgical tracheal intubation general anesthesia were selected in the hospital from January in 2013 to August in 2014.They were randomly divided into the control group and the experimental group e -venly (n=50 in each group).They received 1 or 0.6μg/kg of dexmedetomidine, respectively.Baseline observation records in the two groups before 15min (T0), inducing immediate (T1), immediately before intubation (T2), 1 min after intubation (T3), mean arterial pressure (MAP), respiratory (HR), heart rate (RR), blood oxygen saturation (SpO2), systolic blood pressure (SBP), diyuastolic blood pressure ( DBP) , adverse reactions were observed .The noninferiority analysis were also performed .Results HR, RR, SpO2 ,SBP and DBP decreased in two groups after anesthesia or intubation .Variation rate of post-intubation 1 min MAP in experimental or control group were 15.3%and 15.1%, respectively.The adverse effects rates in experimental group was more lower than control group .Conclu-sion Inhibition of anesthesia intubation -induced cardiovascular response in non -senile hypertension patients by 0.6 or 1.0μg/kg of dexmedetomidine is noinferior .
