CAJ | 학술논문

目的：观察噻托溴铵粉吸入剂治疗慢性阻塞性肺疾病急性加重期（AECOPD）患者的临床疗效。方法：选取 AECOPD 患者130例，随机分为观察组和对照组，各65例，对照组采用常规治疗，观察组在常规治疗的基础上吸入噻托溴铵粉。治疗前及结束后分别观察两组肺功能指标、血气分析指标、慢性阻塞性肺疾病评估测试评分、疗效、生活质量、呼吸困难评分以及不良反应。结果：观察组治疗后肺功能指标、血气分析指标、CAT 评分、生活质量、疗效以及呼吸困难评分均优于对照组，差异有统计学意义。两组均未发现明显不良反应。结论：AECOPD 患者在常规治疗的基础上，使用噻托溴铵粉吸入剂，能明显改善肺功能，提高患者生活质量，临床治疗效果明显。
목적：관찰새탁추안분흡입제치료만성조새성폐질병급성가중기（AECOPD）환자적림상료효。방법：선취 AECOPD 환자130례，수궤분위관찰조화대조조，각65례，대조조채용상규치료，관찰조재상규치료적기출상흡입새탁추안분。치료전급결속후분별관찰량조폐공능지표、혈기분석지표、만성조새성폐질병평고측시평분、료효、생활질량、호흡곤난평분이급불량반응。결과：관찰조치료후폐공능지표、혈기분석지표、CAT 평분、생활질량、료효이급호흡곤난평분균우우대조조，차이유통계학의의。량조균미발현명현불량반응。결론：AECOPD 환자재상규치료적기출상，사용새탁추안분흡입제，능명현개선폐공능，제고환자생활질량，림상치료효과명현。
ObjectiveTo study the clinical efficacy of tiotropium in the treatment of acute exacerbation (AE) of chronic obstructive pulmonary disease (COPD). MethodsDivide 130 cases randomly into observation group (n=65) and control group (n=65). Cases in the observation group used inhaled tiotropium on the basis of routine therapy for the control group. We ob-served the lung functions, blood gas analysis, COPD assessment test (CAT) scores, blood gas analysis, curative effect, quality of life, dyspnea scores and adverse drug reactions of the two groups of patients before and after treatment. ResultsThe observa-tion group was superior to the control group in the lung functions, blood gas analysis, COPD assessment test (CAT) scores, blood gas analysis, curative effect, quality of life and dyspnea scores (P<0.05). No serious adverse reactions were observed in the two groups. ConclusionInhaled tiotropium with routine therapy has a good clinical curative effect and improvements of respisratory function and quality of life in treating patients with AECOPD.