CAJ | 학술논문

目的：探讨肝细胞肝癌(Hepatocellular carcinoma, HCC)的多层螺旋CT(Multislice computed tomography, MSCT)征象与肿瘤血管生成的相关性。方法运用免疫组织化学Elivison法检测41例HCC组织缺氧诱导因子-1α(Hypoxia-inducible factor-1α, HIF-1α)、血管内皮生长因子(Vascular endothelial growth factor,VEGF)的表达及微血管密度(Microvessel density, MVD)。所有病例术前均行MSCT平扫及增强扫描。结果 HIF-1α、VEGF表达及MVD值在瘤体直径≤5cm组和>5cm组的差异均无统计学意义(P>0.05)；在边缘假包膜欠完整或无假包膜组和假包膜完整组、侵袭转移高危组和侵袭转移低危组、以及动脉供血和双重供血组的差异均有统计学意义(P<0.05)。结论 HCC的MSCT征象与HIF-1α、VEGF表达及MVD值密切相关；MSCT征象可以反映HCC病理及生物学特性。
목적：탐토간세포간암(Hepatocellular carcinoma, HCC)적다층라선CT(Multislice computed tomography, MSCT)정상여종류혈관생성적상관성。방법운용면역조직화학Elivison법검측41례HCC조직결양유도인자-1α(Hypoxia-inducible factor-1α, HIF-1α)、혈관내피생장인자(Vascular endothelial growth factor,VEGF)적표체급미혈관밀도(Microvessel density, MVD)。소유병례술전균행MSCT평소급증강소묘。결과 HIF-1α、VEGF표체급MVD치재류체직경≤5cm조화>5cm조적차이균무통계학의의(P>0.05)；재변연가포막흠완정혹무가포막조화가포막완정조、침습전이고위조화침습전이저위조、이급동맥공혈화쌍중공혈조적차이균유통계학의의(P<0.05)。결론 HCC적MSCT정상여HIF-1α、VEGF표체급MVD치밀절상관；MSCT정상가이반영HCC병리급생물학특성。
Objective To explore the correlation between multislice computed tomography (MSCT) features and angiogenesis in hepatocellular carcinoma (HCC).Methods Forty-one cases of surgically excised HCC tissue samples that were pathologically diagnosed were analyzed by Elivisonimmunohistochemistry to detect the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) and assess microvessel density (MVD). All of the patients were preoperatively examined with plain and enhanced CT.Results The differences of positive expression rates of HIF-1α and VEGF and the MVD values in HCC with a tumor diameter ≤ 5cm and >5 cm were not statistically significant (P>0.05). The positive expression rates of HIF-1α and VEGF and the MVD values in tumors with ruptured pseudocapsules or without pseudocapsules, a high risk of metastasis and invasion, and arterial blood were higher than those in tumors with intact capsules, a low risk of metastasis and invasion, and double blood supply, the group differences were statistically significant(P<0.05).Conclusion MSCT manifestations of HCC with HIF-1 alpha, closely related to the expression of VEGF and MVD value; MSCT signs can reflect HCC pathological and biological characteristics.