CAJ | 학술논문

目的探讨血清中补体B因子及免疫球蛋白IgA、IgG、IgM含量的检测在强直性脊柱炎( AS)诊疗中的应用价值.方法在全自动特定蛋白分析仪上采用免疫速率散射比浊法测定AS患者组及健康对照组血清中补体B因子( CFB)及免疫球蛋白IgA、IgG、IgM含量,流式细胞术分析两组人群HLA-B27表达情况,进一步分析指标间的关系. 结果 AS患者组HLA-B27阳性率极高,且血清中CFB、IgA和IgG含量均增高,与对照组相比差异有统计学意义(P<0.01),AS患者血清CFB升高与免疫球蛋白升高无明显相关性(P>0.05),而IgA和IgG含量升高有一定程度相关性(P<0.05). 结论血清中CFB及免疫球蛋白IgA、IgG、IgM含量的检测对AS的临床诊断和治疗提供重要的依据.
목적 탐토혈청중보체B인자급면역구단백IgA、IgG、IgM함량적검측재강직성척주염( AS)진료중적응용개치.방법 재전자동특정단백분석의상채용면역속솔산사비탁법측정AS환자조급건강대조조혈청중보체B인자( CFB)급면역구단백IgA、IgG、IgM함량,류식세포술분석량조인군HLA-B27표체정황,진일보분석지표간적관계. 결과 AS환자조HLA-B27양성솔겁고,차혈청중CFB、IgA화IgG함량균증고,여대조조상비차이유통계학의의(P<0.01),AS환자혈청CFB승고여면역구단백승고무명현상관성(P>0.05),이IgA화IgG함량승고유일정정도상관성(P<0.05). 결론 혈청중CFB급면역구단백IgA、IgG、IgM함량적검측대AS적림상진단화치료제공중요적의거.
Objective To detect the serum levels of complement factor B and immunoglobulins in patients with ankylosing spondyli -tis ( AS) , and analyze application value in the diagnosis and treatment of AS .Methods Immune rate nephelometry was used to detect complement factor B and immunoglobulins on Immage ? 800 Rate Nephelometer (Beckman Coulter Inc.Brea, CA, USA),and HLA-B27 was measured in AS and health controls .Results The positive rate of HLA-B27 was extremely high in AS patients .Serum complement factor B and immunoglobulins(IgA and IgG)in AS patients were significantly higher than those of health controls (P<0.01).And the ele-vated concentration of CFB in AS patients had no significant correlation with those of serum immunoglobulins , while there was certainly positive correlation between the increased serum level of IgA and those of IgG .Conclusion Detecting the concentration of CFB and im-munoglobulins(IgA ,IgG and IgM) provides an important basis for clinical diagnosis and treatment of AS .