医学研究杂志
醫學研究雜誌
의학연구잡지
Journal of Medical Research
2015年
10期
103-106
,共4页
免疫性血小板减少症%人细小病毒B19%儿童
免疫性血小闆減少癥%人細小病毒B19%兒童
면역성혈소판감소증%인세소병독B19%인동
Immune thrombocytopenia%Human parvovirus B19%Childhood
目的 明确人细小病毒B19(human parvovirus B19,B19)感染对儿童新诊断免疫性血小板减少症(immune thrombo-cytopenia, ITP)的影响. 方法 选取2011年1月~2013年12月间416例首次住院并确诊为新诊断ITP患儿为疾病组;随机选取无血小板减少及其他血液系统疾病的普通呼吸道感染住院患儿130例作为对照组. ITP患儿及对照组儿童按年龄段分为<1岁组(n=187)、1~3岁组(n=127)、3~7岁组(n=71)、7~14岁组(n=31). 观察各年龄段患儿B19感染率,疾病组中B19感染阳性及阴性ITP患儿经过相同治疗后的预后情况. 结果 疾病组中B19感染率较对照组各年龄段B19感染率为高,差异均无统计学意义(P均>0.05). ITP患儿均未接受针对B19的相关抗病毒治疗,而针对血小板减少经丙种球蛋白和(或)激素治疗后,疾病组与对照组患儿PLT缓解率差异无统计学意义,与各年龄段B19阴性的ITP患儿治疗后缓解率比较差异均无统计学意义(P均>0.05). 结论 B19感染可能不是新诊断ITP患儿发病的一个主要致病因素;是否治疗B19并不影响儿童急性ITP的治疗效果,因此B19感染的新诊断ITP患儿无需同时接受B19抗病毒的相关治疗.
目的 明確人細小病毒B19(human parvovirus B19,B19)感染對兒童新診斷免疫性血小闆減少癥(immune thrombo-cytopenia, ITP)的影響. 方法 選取2011年1月~2013年12月間416例首次住院併確診為新診斷ITP患兒為疾病組;隨機選取無血小闆減少及其他血液繫統疾病的普通呼吸道感染住院患兒130例作為對照組. ITP患兒及對照組兒童按年齡段分為<1歲組(n=187)、1~3歲組(n=127)、3~7歲組(n=71)、7~14歲組(n=31). 觀察各年齡段患兒B19感染率,疾病組中B19感染暘性及陰性ITP患兒經過相同治療後的預後情況. 結果 疾病組中B19感染率較對照組各年齡段B19感染率為高,差異均無統計學意義(P均>0.05). ITP患兒均未接受針對B19的相關抗病毒治療,而針對血小闆減少經丙種毬蛋白和(或)激素治療後,疾病組與對照組患兒PLT緩解率差異無統計學意義,與各年齡段B19陰性的ITP患兒治療後緩解率比較差異均無統計學意義(P均>0.05). 結論 B19感染可能不是新診斷ITP患兒髮病的一箇主要緻病因素;是否治療B19併不影響兒童急性ITP的治療效果,因此B19感染的新診斷ITP患兒無需同時接受B19抗病毒的相關治療.
목적 명학인세소병독B19(human parvovirus B19,B19)감염대인동신진단면역성혈소판감소증(immune thrombo-cytopenia, ITP)적영향. 방법 선취2011년1월~2013년12월간416례수차주원병학진위신진단ITP환인위질병조;수궤선취무혈소판감소급기타혈액계통질병적보통호흡도감염주원환인130례작위대조조. ITP환인급대조조인동안년령단분위<1세조(n=187)、1~3세조(n=127)、3~7세조(n=71)、7~14세조(n=31). 관찰각년령단환인B19감염솔,질병조중B19감염양성급음성ITP환인경과상동치료후적예후정황. 결과 질병조중B19감염솔교대조조각년령단B19감염솔위고,차이균무통계학의의(P균>0.05). ITP환인균미접수침대B19적상관항병독치료,이침대혈소판감소경병충구단백화(혹)격소치료후,질병조여대조조환인PLT완해솔차이무통계학의의,여각년령단B19음성적ITP환인치료후완해솔비교차이균무통계학의의(P균>0.05). 결론 B19감염가능불시신진단ITP환인발병적일개주요치병인소;시부치료B19병불영향인동급성ITP적치료효과,인차B19감염적신진단ITP환인무수동시접수B19항병독적상관치료.
Objective To confirm the role of human parvovirus B 19 ( B19) infection in childhood immune thrombocytopenia ( ITP) patients.Methods A total of 416 cases of newly diagnosed childhood ITP patients from Jan .2011 to Dec.2013 had been summarized to be cases group , Then a total of 130 childhood patients with common respiratory tract infection were selected randomly as the control group . All patients had been divided in grouped by age as <1 years group(n=187), 1-3 years group(n=127), 3-7 years group(n=71), and 7-14 years group(n=31).The incidence rate of B19 infection in all age groups, the prognosis conditions in B19 infection positive and negative groups after the same therapy protocol were obserred .Results The B19 infection rate had no statistical significance in re-search groups and control groups .And no significant difference in the same age groups compared with control groups (all P>0.05) was found.All the ITP patients had not been given anti -B19 treatment.The PLT remission rate,respectively, after treated with the same pro-tocol including glucocorticoid and/or immunoglobulin had a declining trend as the ages increasing .The B19 infection groups of all ages al-so had no significant difference PLT remission rate had been confirmed in non -B19 infection patients in each age groups (all P>0.05). Conclusions B19 infection may not be a major cause in childhood newly ITP , and treatment protocol with no anti -B19 treatment had no influence on the clinical curative efficacy .
