CAJ | 학술논문

报道1例成人自身免疫性肠病的临床资料,并结合31例文献病例分析该病的临床症状、内镜下表现、病理检查表现和自身免疫学检查.结果显示,32例自身免疫性肠病患者的主要症状均为慢性腹泻(100％)和吸收不良(100％);小肠黏膜病理表现包括小肠绒毛萎缩可见上皮内少量淋巴细胞;部分患者(15/32)同时患有其他自身免疫性疾病,伴有多种自身抗体阳性(其中抗肠上皮抗体阳性者20例,抗小肠杯状细胞抗体阳性者7例,抗核抗体阳性者9例);多数患者(27/32)使用激素或其他免疫抑制治疗有效.提示,成人自身免疫性肠病是以顽固腹泻和吸收不良为主要表现,可以合并多种自身免疫病的疾病.
보도1례성인자신면역성장병적림상자료,병결합31예문헌병례분석해병적림상증상、내경하표현、병리검사표현화자신면역학검사.결과현시,32례자신면역성장병환자적주요증상균위만성복사(100％)화흡수불량(100％);소장점막병리표현포괄소장융모위축가견상피내소량림파세포;부분환자(15/32)동시환유기타자신면역성질병,반유다충자신항체양성(기중항장상피항체양성자20례,항소장배상세포항체양성자7례,항핵항체양성자9례);다수환자(27/32)사용격소혹기타면역억제치료유효.제시,성인자신면역성장병시이완고복사화흡수불량위주요표현,가이합병다충자신면역병적질병.
One case was selected from our hospital and another 31 cases from literature.Symptoms, endoscopic and pathological manifestations and autoimmune examinations of all cases were summarized and analyzed.Their major symptoms were prolonged diarrhea (100％) and malabsorption (100％).Specific small bowel histology indicated villous blunting and minimal intraepithelial lymphocytosis.And 15 of them had some other autoimmune diseases.And many positive autoimmune antibodies were detected, including anti-enterocyte antibodies (n =20), anti-intestinal goblet cell antibody (n =7) and anti-nuclear antibody (n =9).Most patients (27/32) responded to corticosteroids.Adult autoimmune enteropathy is a rare syndrome with intractable diarrhea and malabsorption.And it may be accompanied by other autoimmune diseases in some cases.