中华全科医师杂志
中華全科醫師雜誌
중화전과의사잡지
Chinese Journal of General Practitioners
2015年
10期
765-767
,共3页
肝细胞生长因子%糖尿病肾病
肝細胞生長因子%糖尿病腎病
간세포생장인자%당뇨병신병
Hepatocyte growth factor%Diabetic nephropathies
回顾性分析我院2010年1月至2013年10月收治的207例2型糖尿病患者血清肝细胞生长因子(HGF)水平.其中56例为非糖尿病肾病[尿白蛋白排泄率(UAER) ＜20 μg/min],55例为早期糖尿病肾病(UAER 20 ～ 200 μg/min),52例为临床期糖尿病肾病肾功能正常者(UAER＞200 μg/min),44例为临床期糖尿病肾病肾功能异常者(UAER＞ 200 μg/min,肌酐133 ～ 177 μmol/L),HGF水平分别为(400.1±39.3)、(689.4±55.6)、(967.3 ±68.5)和(150.7±23.2) ng/L,55例正常对照者为(256.4±30.4)ng/L.2型糖尿病不同病变程度糖尿病肾病患者的血清HGF存在差异.
迴顧性分析我院2010年1月至2013年10月收治的207例2型糖尿病患者血清肝細胞生長因子(HGF)水平.其中56例為非糖尿病腎病[尿白蛋白排洩率(UAER) ＜20 μg/min],55例為早期糖尿病腎病(UAER 20 ～ 200 μg/min),52例為臨床期糖尿病腎病腎功能正常者(UAER＞200 μg/min),44例為臨床期糖尿病腎病腎功能異常者(UAER＞ 200 μg/min,肌酐133 ～ 177 μmol/L),HGF水平分彆為(400.1±39.3)、(689.4±55.6)、(967.3 ±68.5)和(150.7±23.2) ng/L,55例正常對照者為(256.4±30.4)ng/L.2型糖尿病不同病變程度糖尿病腎病患者的血清HGF存在差異.
회고성분석아원2010년1월지2013년10월수치적207례2형당뇨병환자혈청간세포생장인자(HGF)수평.기중56례위비당뇨병신병[뇨백단백배설솔(UAER) ＜20 μg/min],55례위조기당뇨병신병(UAER 20 ～ 200 μg/min),52례위림상기당뇨병신병신공능정상자(UAER＞200 μg/min),44례위림상기당뇨병신병신공능이상자(UAER＞ 200 μg/min,기항133 ～ 177 μmol/L),HGF수평분별위(400.1±39.3)、(689.4±55.6)、(967.3 ±68.5)화(150.7±23.2) ng/L,55례정상대조자위(256.4±30.4)ng/L.2형당뇨병불동병변정도당뇨병신병환자적혈청HGF존재차이.
To explore the serum hepatocyte growth factor (HGF) lesion severity level and diabetic nephropathy (DN).A total of 207 patients with type 2 diabetes mellitus (T2DM) were recruited from Second Municipal Hospital.According to the level of urinary albumin excretion rate (UAER), they were divided into non-DN group (group A, n =56) : UAER ＜ 20 μg/min;early DN (group B, n =55) : UAER: 20-200 μg/min;clinical stage DN with normal renal function (group C, n =52):UAER ＞ 200 μg/min;DN in clinical renal dysfunction (group D, n =44) : UAER ＞ 200 μmol/min, decompensated chronic renal failure (serum creatinine: 133-177 μmol/L).And 55 healthy subjects were selected as controls.The serum levels of HGF, fasting plasma glucose , plasma glucose at 2 hour , blood urea nitrogen, creatinine and glycosylated hemoglobin were determined.HGF value : control group : (256.4 ± 30.4) ng/L,group A: (400.1 ±39.3)ng/L, group B: (689.4 ±55.6) ng/L, group C:(967.3 ±68.5) ng/L and group D: (150.7 ±23.2) ng/L.There are differences of serum HGF in different degree of DN.
