中国药师
中國藥師
중국약사
China Pharmacist
2015年
11期
1909-1910,1911
,共3页
多烯磷脂胆碱%甲亢肝损害%肝功能%甘草酸二铵
多烯燐脂膽堿%甲亢肝損害%肝功能%甘草痠二銨
다희린지담감%갑항간손해%간공능%감초산이안
Polyene phosphatidylcholine%Hyperthyroidism liver damage%Liver function%Diammonium glycyrrhizinate
目的：：观察烯磷酯酰胆碱联合甘草酸二铵治疗甲亢肝损害患者的临床疗效。方法：45例甲亢肝功能损害患者按入院先后顺序分为两组,均使用抗甲状腺药物进行常规治疗,对照组加用甘草酸二铵胶囊150 mg,po,tid,观察组在对照组基础上再加用多烯磷脂胆碱注射液232.5 mg,ivd,qd。治疗30 d后观察两组患者疗效、肝功能指标变化以及药品不良反应发生情况。结果：观察组患者总有效率为95.66%,明显高于对照组的63.63%(P<0.01)。治疗后,两组患者ALT和AST水平均较治疗前显著降低(P<0.05)；且观察组ALT和AST水平明显低于同期对照组(P<0.05)。两组Alb治疗前后无明显变化(P>0.05)。观察组患者未见药品不良发应发生。结论：多烯磷酯酰胆碱联合甘草酸二铵治疗的甲亢肝损害临床疗较确切,可显著改善患者肝功能水平,且不良反应少,安全性高,值得临床推广。
目的：：觀察烯燐酯酰膽堿聯閤甘草痠二銨治療甲亢肝損害患者的臨床療效。方法：45例甲亢肝功能損害患者按入院先後順序分為兩組,均使用抗甲狀腺藥物進行常規治療,對照組加用甘草痠二銨膠囊150 mg,po,tid,觀察組在對照組基礎上再加用多烯燐脂膽堿註射液232.5 mg,ivd,qd。治療30 d後觀察兩組患者療效、肝功能指標變化以及藥品不良反應髮生情況。結果：觀察組患者總有效率為95.66%,明顯高于對照組的63.63%(P<0.01)。治療後,兩組患者ALT和AST水平均較治療前顯著降低(P<0.05)；且觀察組ALT和AST水平明顯低于同期對照組(P<0.05)。兩組Alb治療前後無明顯變化(P>0.05)。觀察組患者未見藥品不良髮應髮生。結論：多烯燐酯酰膽堿聯閤甘草痠二銨治療的甲亢肝損害臨床療較確切,可顯著改善患者肝功能水平,且不良反應少,安全性高,值得臨床推廣。
목적：：관찰희린지선담감연합감초산이안치료갑항간손해환자적림상료효。방법：45례갑항간공능손해환자안입원선후순서분위량조,균사용항갑상선약물진행상규치료,대조조가용감초산이안효낭150 mg,po,tid,관찰조재대조조기출상재가용다희린지담감주사액232.5 mg,ivd,qd。치료30 d후관찰량조환자료효、간공능지표변화이급약품불량반응발생정황。결과：관찰조환자총유효솔위95.66%,명현고우대조조적63.63%(P<0.01)。치료후,량조환자ALT화AST수평균교치료전현저강저(P<0.05)；차관찰조ALT화AST수평명현저우동기대조조(P<0.05)。량조Alb치료전후무명현변화(P>0.05)。관찰조환자미견약품불량발응발생。결론：다희린지선담감연합감초산이안치료적갑항간손해림상료교학절,가현저개선환자간공능수평,차불량반응소,안전성고,치득림상추엄。
Objective:To observe the curative effect of polyene phosphatidylcholine injection combined with diammonium glycyr-rhizinate in the treatment of liver damage in the patients with hyperthyroidism. Methods:Totally 45 cases of hyperthyroidism patients with impaired liver function were divided into two groups according to the order of admission and treated with anti-thyroid drugs in the conventional treatment. The control group was treated with diammonium glycyrrhizinate capsules 150 mg, po, tid, and the observation group was treated with polyene phosphatidylcholine injection 232. 5 mg, ivd, qd on the basis of the control group. After 30-day treat-ment, the clinical curative effect, changes in liver function and the incidence of adverse drug reactions of the two groups were observed and compared. Results:The total effective rate of the observation group was 95. 66%, which was significantly higher than that of the control group (63. 63%, P<0. 01). After the treatment, the ALT and AST levels in the two groups were significantly lower than those before the treatment (P<0. 05), and the decrease in the observation group was more significant than that in the control group (P<0. 05). No significant change in Alb was shown before and after the treatment (P>0. 05). No adverse drug reaction was shown in the observation group. Conclusion: Polyene phosphatidylcholine injection combined with diammonium glycyrrhizinate exhibits promising efficacy in the treatment of hyperthyroidism liver damage, which can significantly improve liver function in the patients with few adverse reactions and high safety, and is worthy of clinical promotion.
