CAJ | 학술논문

目的：目的了解成都市已婚妇女宫颈人乳头状瘤病毒（ HPV）感染情况和基因亚型分布。方法分析2012年10月至2013年9月在我院行健康体检的1482例妇女的HPV感染情况以及亚型和年龄分布情况。结果1482例宫颈筛查标本中，HPV阳性标本197例（13.29％）。单一型别HPV感染率为11.47％，混合型别HPV感染率为1.82％。197例HPV感染者中共有19种 HPV亚型被检出，高危型以52、58为主，其次为16、68型，阳性率分别为21.31％、10.00％和9.13％、6.96％。中国人群常见型CP8304阳性率为11.74％。60岁及以上的妇女HPV及高危型HPV感染阳性率最高，其次为20～29岁年龄组，阳性率最低的为40～49岁年龄组妇女。结论本地区HPV感染率较高，感染主要亚型是52、58、16型，以单一感染为主，此分布特点对本地区HPV感染、宫颈癌及癌前病变的防治有重要意义。
목적：목적료해성도시이혼부녀궁경인유두상류병독（ HPV）감염정황화기인아형분포。방법분석2012년10월지2013년9월재아원행건강체검적1482례부녀적HPV감염정황이급아형화년령분포정황。결과1482례궁경사사표본중，HPV양성표본197례（13.29％）。단일형별HPV감염솔위11.47％，혼합형별HPV감염솔위1.82％。197례HPV감염자중공유19충 HPV아형피검출，고위형이52、58위주，기차위16、68형，양성솔분별위21.31％、10.00％화9.13％、6.96％。중국인군상견형CP8304양성솔위11.74％。60세급이상적부녀HPV급고위형HPV감염양성솔최고，기차위20～29세년령조，양성솔최저적위40～49세년령조부녀。결론본지구HPV감염솔교고，감염주요아형시52、58、16형，이단일감염위주，차분포특점대본지구HPV감염、궁경암급암전병변적방치유중요의의。
Objective To evaluate the prevalence of human papillomavirus(HPV)infection and subtype distribution among health examination women in Chengdu.Methods A total of 1,482 samples were collected from health examination women for HPV subtype analysis between October 2012 and September 2013.The overall HPV prevalence,infectious status of various subtypes and age distribution were compared and analyzed.Results Among the 1,482 women,197 cases were infected with HPV.The overall HPV prev-alence was 13.29%.The single HPV infection rate was 11.47%.The multiple infection rates were 1.82%.Among 21 genotypes of HPV,19 genotypes were detected and the main high-risk genotypes were HPV52,58,16 and 68.The highest HPV prevalence rate was found in women at and over 60 years old followed by those aged from 20 to 29.The lowest HPV prevalence rate was found in women aged from 40 to 49.Conclusion The infection rate of HPV was high in Chengdu.The main genotypes were HPV 52,58 and 16,which were primarily in a single infection.The distribution character has an important value in the prevention and treatment of HPV infection, cervical cancer and precancerous lesions.