CAJ | 학술논문

目的：探讨生殖免疫抗体在女性复发性流产诊治中的临床意义。方法2013年8月至2014年7月在四川省妇幼保健院生殖医学中心就诊的复发性流产患者212例作为研究组，孕前检查女性526例作为对照组，采用酶联免疫吸附方法（ ELISA）检测生殖免疫抗体，比较两组生殖免疫抗体检测阳性率的差异。结果研究组抗HCG抗体（ anti-hCG antibody， AHCGAb）、抗精子抗体（ anti-sperm antibody，AsAb）、抗卵巢抗体（ anti-ovarian antibody，AOVAb）、抗子宫内膜抗体（ anti-endome-trial antibody，AEMAb）、抗心磷脂抗体（ anti-cardiolipin antibody-IgG，ACA-IgG）阳性率均高于对照组，差异有统计学意义（ P＜0.05）。研究组各年龄段生殖免疫抗体阳性率差异无统计学意义（P＞0.05）。结论生殖免疫抗体检测在女性复发性流产诊治中有重要临床意义，ACA-IgG是最重要的免疫影响因素，有必要对复发性流产女性进行检测和治疗。
목적：탐토생식면역항체재녀성복발성유산진치중적림상의의。방법2013년8월지2014년7월재사천성부유보건원생식의학중심취진적복발성유산환자212례작위연구조，잉전검사녀성526례작위대조조，채용매련면역흡부방법（ ELISA）검측생식면역항체，비교량조생식면역항체검측양성솔적차이。결과연구조항HCG항체（ anti-hCG antibody， AHCGAb）、항정자항체（ anti-sperm antibody，AsAb）、항란소항체（ anti-ovarian antibody，AOVAb）、항자궁내막항체（ anti-endome-trial antibody，AEMAb）、항심린지항체（ anti-cardiolipin antibody-IgG，ACA-IgG）양성솔균고우대조조，차이유통계학의의（ P＜0.05）。연구조각년령단생식면역항체양성솔차이무통계학의의（P＞0.05）。결론생식면역항체검측재녀성복발성유산진치중유중요림상의의，ACA-IgG시최중요적면역영향인소，유필요대복발성유산녀성진행검측화치료。
Objective To explore the clinical values of reproductive autoantibodies in the diagnosis and treatment of recurrent miscarriage.Methods From August 2013 to July 2014,212 women with recurrent spontaneous abortion who were treated in our hospi-tal were used as study group.At the same time,526 women with preconception examination were used as control group.The reproductive autoantibodies were measured by using ELISAs,and the positive rate was compared between the two groups.Results The positive rate in anti-hCG antibody (AHCGAb),anti-sperm antibody (AsAb),anti-ovarian antibody (AOVAb),anti-endometrial antibody (AEM-Ab),anti-cardiaolipin andibody-IgG (ACA-IgG) in the study group were significantly higher than that in the control group (all P <0.05).However,there were no significant differences in positive rates of reproductive autoantibodies in the participants with various a-ges ( P >0.05 ) .Conclusion The detection of the reproductive autoantibodies has important a clinical value in the diagnosis and treatment of recurrent spontaneous abortion.ACA is the most important influence factor.It is necessary to detect it when women with re-current spontaneous abortion are being treated.