山西医科大学学报
山西醫科大學學報
산서의과대학학보
Journal of Shanxi Medical University
2015年
10期
1027-1029
,共3页
肺炎支原体%E-选择素%可溶性细胞间黏附分子-1%儿童
肺炎支原體%E-選擇素%可溶性細胞間黏附分子-1%兒童
폐염지원체%E-선택소%가용성세포간점부분자-1%인동
Mycoplasma pneumoniae%E-selectin%sICAM-1%children
目的 探讨E-选择素( E-selectin)与可溶性细胞间黏附分子-1 ( sICAM-1 )在儿童肺炎支原体感染中的应用价值.方法 选取本院儿科急性期肺炎支原体感染的患儿48例,恢复期患儿42例,选取同期体检的40例健康儿童做为对照组,采用ELISA法测定血浆E-selectin和sICAM-1水平. 用ROC曲线评价E-selectin和sICAM-1对急性期肺炎支原体感染的诊断效能;将急性期患儿血浆E-selectin与sICAM-1浓度进行相关性分析. 结果 急性期患儿血浆E-selectin和sICAM-1的水平明显高于恢复期及健康对照组,差异有统计学意义(P<0. 05);E-selectin诊断急性期肺炎支原体肺炎的AUC为0. 852(95%可信区间为0. 751-0. 952),其敏感度为80. 0%,特异度为78. 5%;sICAM-1 诊断急性期肺炎支原体肺炎的 AUC为0. 859 (95%可信区间为0. 764-0. 954),其敏感度为80. 5%,特异度为80. 0%. 急性期患儿E-selectin和sICAM-1水平呈明显正相关(r=0. 758,P<0. 01). 结论 急性期肺炎支原体感染患者血浆E-selectin和sICAM-1水平显著增高,可作为评价肺炎支原体感染病情程度以及治疗疗效观察的重要指标.
目的 探討E-選擇素( E-selectin)與可溶性細胞間黏附分子-1 ( sICAM-1 )在兒童肺炎支原體感染中的應用價值.方法 選取本院兒科急性期肺炎支原體感染的患兒48例,恢複期患兒42例,選取同期體檢的40例健康兒童做為對照組,採用ELISA法測定血漿E-selectin和sICAM-1水平. 用ROC麯線評價E-selectin和sICAM-1對急性期肺炎支原體感染的診斷效能;將急性期患兒血漿E-selectin與sICAM-1濃度進行相關性分析. 結果 急性期患兒血漿E-selectin和sICAM-1的水平明顯高于恢複期及健康對照組,差異有統計學意義(P<0. 05);E-selectin診斷急性期肺炎支原體肺炎的AUC為0. 852(95%可信區間為0. 751-0. 952),其敏感度為80. 0%,特異度為78. 5%;sICAM-1 診斷急性期肺炎支原體肺炎的 AUC為0. 859 (95%可信區間為0. 764-0. 954),其敏感度為80. 5%,特異度為80. 0%. 急性期患兒E-selectin和sICAM-1水平呈明顯正相關(r=0. 758,P<0. 01). 結論 急性期肺炎支原體感染患者血漿E-selectin和sICAM-1水平顯著增高,可作為評價肺炎支原體感染病情程度以及治療療效觀察的重要指標.
목적 탐토E-선택소( E-selectin)여가용성세포간점부분자-1 ( sICAM-1 )재인동폐염지원체감염중적응용개치.방법 선취본원인과급성기폐염지원체감염적환인48례,회복기환인42례,선취동기체검적40례건강인동주위대조조,채용ELISA법측정혈장E-selectin화sICAM-1수평. 용ROC곡선평개E-selectin화sICAM-1대급성기폐염지원체감염적진단효능;장급성기환인혈장E-selectin여sICAM-1농도진행상관성분석. 결과 급성기환인혈장E-selectin화sICAM-1적수평명현고우회복기급건강대조조,차이유통계학의의(P<0. 05);E-selectin진단급성기폐염지원체폐염적AUC위0. 852(95%가신구간위0. 751-0. 952),기민감도위80. 0%,특이도위78. 5%;sICAM-1 진단급성기폐염지원체폐염적 AUC위0. 859 (95%가신구간위0. 764-0. 954),기민감도위80. 5%,특이도위80. 0%. 급성기환인E-selectin화sICAM-1수평정명현정상관(r=0. 758,P<0. 01). 결론 급성기폐염지원체감염환자혈장E-selectin화sICAM-1수평현저증고,가작위평개폐염지원체감염병정정도이급치료료효관찰적중요지표.
Objective To explore the diagnostic value of the E-selectin and sICAM-1 in children suffering from Mycoplasma pneumoniae infection. Methods Clinical data of 48 patients with acute Mycoplasma pneumoniae infection and 42 patients in recovery phase were reviewed, and 40 healthy children were chosen as control group. ELISA was used to detect the levels of E-selectin and sICAM-1, and the receiver operating characteristic(ROC) curve was used to evaluate the diagnosis efficiency of acute Mycoplasma pneumoniae infec-tion. The correlation between E-selectin and sICAM-1 was analyzed in patients with acute Mycoplasma pneumoniae infection. Results The levels of E-selectin and sICAM-1 were significantly higher in acute Mycoplasma pneumoniae infection than those in recovery phase(P<0. 05). The area under ROC curve of E-selectin was 0. 852(95%CI 0. 751-0. 952),and the sensitivity and specificity of the E-selectin were 80. 0% and 78. 5%. The area under ROC curve of sICAM-1 was 0. 859(95%CI 0. 764-0. 954),and the sensitivity and specificity of the sICAM-1 were 80. 5% and 80. 0%. Correlation analysis showed that E-selectin was significantly correlated with sICAM-1(r=0. 758,P<0. 01). Conclusion E-selectin and sICAM-1 can be used as indicators in evaluation of the progression and outcome of children with MP infection.
