医疗装备
醫療裝備
의료장비
Chinese Journal of Medical Device
2015年
13期
2-4
,共3页
癌胚抗原%糖类抗原-199%胸苷激酶l%联合检测%敏感度%特异度
癌胚抗原%糖類抗原-199%胸苷激酶l%聯閤檢測%敏感度%特異度
암배항원%당류항원-199%흉감격매l%연합검측%민감도%특이도
CEA%CA199%CA125%TK1%combination test%sensitivity%specificity
目的：评价血清癌胚抗原（CEA）、糖类抗原-199（CA199）、和胸苷激酶l（TK1）联合检测在诊断结直肠癌中的诊断价值。方法：测定133例结直肠癌患者、103例良性肠病患者血清CEA、CA199和TK1水平，用Logistic回归模型制作ROC曲线，并且计算曲线下面积（AUCROC）以评价各肿瘤标志物的诊断价值。结果：结直肠癌组与良性肠病组的诊断性能评价，结直肠癌组的肿瘤标志物水平大于良性肠病组的肿瘤标志物，差异有统计学意义（Z=-5.185--4.241，P 均<0.05）。各ROC曲线下最佳cut-off值：CEA为3.36 ng/L、CA199为7.90 ng/L和TK1为1.51 pmol/L；各ROC曲线下面积：CEA为0.697，CA199为0.683，TK1为0.661，联合检测为0.757；联合检测的约登指数高。结论：血清CEA、CA199和TK1三项联合检测在结直肠癌的诊断中起到优势互补作用，三项联合检测可增加CRC诊断价值。
目的：評價血清癌胚抗原（CEA）、糖類抗原-199（CA199）、和胸苷激酶l（TK1）聯閤檢測在診斷結直腸癌中的診斷價值。方法：測定133例結直腸癌患者、103例良性腸病患者血清CEA、CA199和TK1水平，用Logistic迴歸模型製作ROC麯線，併且計算麯線下麵積（AUCROC）以評價各腫瘤標誌物的診斷價值。結果：結直腸癌組與良性腸病組的診斷性能評價，結直腸癌組的腫瘤標誌物水平大于良性腸病組的腫瘤標誌物，差異有統計學意義（Z=-5.185--4.241，P 均<0.05）。各ROC麯線下最佳cut-off值：CEA為3.36 ng/L、CA199為7.90 ng/L和TK1為1.51 pmol/L；各ROC麯線下麵積：CEA為0.697，CA199為0.683，TK1為0.661，聯閤檢測為0.757；聯閤檢測的約登指數高。結論：血清CEA、CA199和TK1三項聯閤檢測在結直腸癌的診斷中起到優勢互補作用，三項聯閤檢測可增加CRC診斷價值。
목적：평개혈청암배항원（CEA）、당류항원-199（CA199）、화흉감격매l（TK1）연합검측재진단결직장암중적진단개치。방법：측정133례결직장암환자、103례량성장병환자혈청CEA、CA199화TK1수평，용Logistic회귀모형제작ROC곡선，병차계산곡선하면적（AUCROC）이평개각종류표지물적진단개치。결과：결직장암조여량성장병조적진단성능평개，결직장암조적종류표지물수평대우량성장병조적종류표지물，차이유통계학의의（Z=-5.185--4.241，P 균<0.05）。각ROC곡선하최가cut-off치：CEA위3.36 ng/L、CA199위7.90 ng/L화TK1위1.51 pmol/L；각ROC곡선하면적：CEA위0.697，CA199위0.683，TK1위0.661，연합검측위0.757；연합검측적약등지수고。결론：혈청CEA、CA199화TK1삼항연합검측재결직장암적진단중기도우세호보작용，삼항연합검측가증가CRC진단개치。
Objective:Aim The purpose of the present study was to evaluate the diagnostic efficiency for colorectal cancer (CRC) with the combined analysis of carcino-embryonic antigen (CEA), carbohydrate antigen 199 (CA199) and thymidine kinase 1 (TK1). Methods:Serum levels of CEA, CA199, and TK1 were measured in: 133 patients with CRC and 103 patients with benign colorectal diseases. The diagnostic value was analyzed using the logistic regression equation and receiver operating characteristic curves (ROC). Results:The serum levels of CEA, CA199, and TK1 in patients with CRC were significantly higher than those in patients with benign colorectal diseases (Z= -5.185 to -4.241,P<0.001 in all). Receiver operating characteristic curves (ROC) in patients with CRC versus those with benign colorectal diseases indicated the optimal cut-off value was 3.36 ng/L for CEA, 7.90 ng/L for CA199, and 1.51 pmol/L for TK1. The area under ROC curve (AUC) was 0.697 for CEA, 0.683 for CA199, 0.661 for TK1 and 0.757 for the combination of the tested tumor markers. The combination resulted in a higher Youden index.Conclusion:The conjoint detection of serum CEA, CA199, and TK1 could play complementary role in the diagnosis of CRC and could significantly improve the Youden index for the diagnosis of CRC.
