CAJ | 학술논문

目的：：观察厄贝沙坦治疗高血压合并糖尿病的疗效及对患者尿白蛋白的影响。方法：高血压合并糖尿病患者62例，随机分为观察组(31例)与对照组(31例)。对照组患者给予常规控制血糖、血压治疗，观察组在此基础上加用厄贝沙坦治疗。疗程均为3个月。比较两组患者治疗前后血压及尿白蛋白的变化，评价两组降压疗效及药品不良反应。结果：观察组降压总有效率为96.8%，明显高于对照组的83.9%(P<0.05)。两组患者治疗后收缩压与舒张压均较前明显降低(P<0.05)；两组患者尿白蛋白排除率(UAER)、尿白蛋白(mAlb)较治疗前也明显降低(P<0.05)，且观察组较对照组降低更显著(P<0.05)。两组药品不良反应发生率比较，差异无统计学意义(P>0.05)。结论：厄贝沙坦治疗高血压合并糖尿病临床疗效较好，不良反应发生率较低，并且能够有效保护肾功能。
목적：：관찰액패사탄치료고혈압합병당뇨병적료효급대환자뇨백단백적영향。방법：고혈압합병당뇨병환자62례，수궤분위관찰조(31례)여대조조(31례)。대조조환자급여상규공제혈당、혈압치료，관찰조재차기출상가용액패사탄치료。료정균위3개월。비교량조환자치료전후혈압급뇨백단백적변화，평개량조강압료효급약품불량반응。결과：관찰조강압총유효솔위96.8%，명현고우대조조적83.9%(P<0.05)。량조환자치료후수축압여서장압균교전명현강저(P<0.05)；량조환자뇨백단백배제솔(UAER)、뇨백단백(mAlb)교치료전야명현강저(P<0.05)，차관찰조교대조조강저경현저(P<0.05)。량조약품불량반응발생솔비교，차이무통계학의의(P>0.05)。결론：액패사탄치료고혈압합병당뇨병림상료효교호，불량반응발생솔교저，병차능구유효보호신공능。
Objective:To explore the effect of irbesartan in the treatment of the patients with hypertension complicated with diabetes mellitus and its influence on urine trace albumin. Methods:Totally 62 cases of patients with hypertension complicated with diabetes mel-litus were divided into the observation group and the control group randomly with 31 patients in each. The patients in the control group were given the conventional blood sugar and blood pressure control, and the patients in the observation group were treated with irbesartan additionally. The treatment course was 3 months. The changes of blood pressure and urine trace albumin of the patients in the two groups before and after the treatment were compared, and the effect of blood pressure control and the adverse effects were evaluated as well. Re-sults:The total effective rate of the observation group was 96. 8%, which was much higher than that of the control group (83. 9%, P<0. 05) , and the difference had statistical significance (P<0. 05). After the treatment, the systolic blood pressure and diastolic blood pressure of the patients in the two groups were reduced significantly (P<0. 05), and the urinary albumin excretion rate (UAER) and the level of urine trace albumin (mAlb) of the patients in the two groups were obviously lowered (P<0. 05), and the decrease in the obser-vation group was more notable than that in the control group (P<0. 05). No significant difference in the incidence of adverse reactions was shown between the two groups(P>0. 05). Conclusion:The clinical effect of irbesartan in the treatment of patients with hypertension complicated with diabetes mellitus is promising with low incidence of adverse effects,which can effectively protect renal function as well.