中国药师
中國藥師
중국약사
China Pharmacist
2015年
11期
1925-1927,1977
,共4页
奥美拉唑%西咪替丁%药物预防%应激性溃疡%Meta分析
奧美拉唑%西咪替丁%藥物預防%應激性潰瘍%Meta分析
오미랍서%서미체정%약물예방%응격성궤양%Meta분석
Omeprazole%Cimetidine%Medication prophylaxis%Stress ulcer%Meta-analysis
目的：：对奥美拉唑与西咪替丁预防应激性溃疡出血的临床效果进行评价,为临床应用提供循证医学证据。方法：以“奥美拉唑”、“西咪替丁”、“应激性溃疡”等为主题词或关键词检索PubMed、Medline、CNKI、万方及维普数据库。两名研究员独立提取资料,并对其方法学质量进行评价。对符合纳入标准的研究采用RevMan5.2软件进行Meta分析。结果：共纳入17个随机对照试验(奥美拉唑组患者892例,西咪替丁组患者888例)。 Meta分析结果显示,在应激性溃疡出血发生率方面,奥美拉唑组与西咪替丁组的差异有统计学意义(OR=0.23,95%CI：0.17~0.32,P<0.00001)。结论：现有文献分析结果表明,在预防应激性溃疡出血方面,奥美拉唑较西咪替丁可能具有更好的疗效。
目的：：對奧美拉唑與西咪替丁預防應激性潰瘍齣血的臨床效果進行評價,為臨床應用提供循證醫學證據。方法：以“奧美拉唑”、“西咪替丁”、“應激性潰瘍”等為主題詞或關鍵詞檢索PubMed、Medline、CNKI、萬方及維普數據庫。兩名研究員獨立提取資料,併對其方法學質量進行評價。對符閤納入標準的研究採用RevMan5.2軟件進行Meta分析。結果：共納入17箇隨機對照試驗(奧美拉唑組患者892例,西咪替丁組患者888例)。 Meta分析結果顯示,在應激性潰瘍齣血髮生率方麵,奧美拉唑組與西咪替丁組的差異有統計學意義(OR=0.23,95%CI：0.17~0.32,P<0.00001)。結論：現有文獻分析結果錶明,在預防應激性潰瘍齣血方麵,奧美拉唑較西咪替丁可能具有更好的療效。
목적：：대오미랍서여서미체정예방응격성궤양출혈적림상효과진행평개,위림상응용제공순증의학증거。방법：이“오미랍서”、“서미체정”、“응격성궤양”등위주제사혹관건사검색PubMed、Medline、CNKI、만방급유보수거고。량명연구원독립제취자료,병대기방법학질량진행평개。대부합납입표준적연구채용RevMan5.2연건진행Meta분석。결과：공납입17개수궤대조시험(오미랍서조환자892례,서미체정조환자888례)。 Meta분석결과현시,재응격성궤양출혈발생솔방면,오미랍서조여서미체정조적차이유통계학의의(OR=0.23,95%CI：0.17~0.32,P<0.00001)。결론：현유문헌분석결과표명,재예방응격성궤양출혈방면,오미랍서교서미체정가능구유경호적료효。
Objective:To evaluate the efficacy of omeprazole and cimetidine in the prophylaxis of stress ulcer bleeding to provide evidence for clinical therapy in China. Methods:The randomized controlled trials were searched in PubMed, Medline, CNKI, Wan-fang and Vip database with the key words of omeprazole, cimetidine and stress ulcer. Two evaluators assessed the quality and reviewed the data independently. RevMan 5. 2 software was used for Meta-analysis. Results:Seventeen randomized controlled trials were includ-ed involving 892 patients for omeprazole group and 888 patients for cimetidine group. The results of Meta-analysis showed that the difference between the two groups after the treatment was statistically significant by comparing the incidence of stress ulcer bleeding (OR=0. 23,95% CI:0. 17-0. 32;P<0. 000 01). The incidence of stress ulcer bleeding of omeprazole group was significantly lower than that of cimetidine group. Conclusion:Existing literature analysis shows that omeprazole is more effective than cimetidine in the stress ulcer bleeding prophylaxis.
