中国药师
中國藥師
중국약사
China Pharmacist
2015年
11期
1899-1901
,共3页
五苓胶囊%骨化三醇%早期糖尿病肾病%尿标记性蛋白
五苓膠囊%骨化三醇%早期糖尿病腎病%尿標記性蛋白
오령효낭%골화삼순%조기당뇨병신병%뇨표기성단백
Wuling capsules%Calcitriol%Early diabetic nephropathy%Urine marker proteins
目的：：观察五苓胶囊联合骨化三醇对早期糖尿病肾病( DN)患者尿标记性蛋白的影响。方法：64例早期DN患者随机分为对照组及观察组各32例,两组均进行适宜饮食及运动、蛋白质摄入量相对恒定并优化降糖方案,观察组同时加服五苓胶囊(0.9 g, po tid)及骨化三醇胶丸0.25μg, po qd,连续8周。观察两组患者治疗前后空腹血糖( FBG)及餐后2 h 血糖(2hBG)、糖化血红蛋白(HbA1c)、超敏C反应蛋白(hs-CRP)、尿总蛋白、尿白蛋白排泄量(Alb)、尿β2微球蛋白(β2-MG),尿视黄醇结合蛋白(RBP)等变化。结果：两组治疗后FBG、2hBG、HbA1c、hs-CRP、尿总蛋白、Alb及RBP值均较治疗前明显改善,差异有统计学意义(P<0.05)；且观察组治疗后尿总蛋白、Alb、β2-MG、RBP及hs-CRP值明显优于对照组(P<0.05)。结论：五苓胶囊联合骨化三醇可有效减轻早期DN患者肾小球及肾小管的损伤。
目的：：觀察五苓膠囊聯閤骨化三醇對早期糖尿病腎病( DN)患者尿標記性蛋白的影響。方法：64例早期DN患者隨機分為對照組及觀察組各32例,兩組均進行適宜飲食及運動、蛋白質攝入量相對恆定併優化降糖方案,觀察組同時加服五苓膠囊(0.9 g, po tid)及骨化三醇膠汍0.25μg, po qd,連續8週。觀察兩組患者治療前後空腹血糖( FBG)及餐後2 h 血糖(2hBG)、糖化血紅蛋白(HbA1c)、超敏C反應蛋白(hs-CRP)、尿總蛋白、尿白蛋白排洩量(Alb)、尿β2微毬蛋白(β2-MG),尿視黃醇結閤蛋白(RBP)等變化。結果：兩組治療後FBG、2hBG、HbA1c、hs-CRP、尿總蛋白、Alb及RBP值均較治療前明顯改善,差異有統計學意義(P<0.05)；且觀察組治療後尿總蛋白、Alb、β2-MG、RBP及hs-CRP值明顯優于對照組(P<0.05)。結論：五苓膠囊聯閤骨化三醇可有效減輕早期DN患者腎小毬及腎小管的損傷。
목적：：관찰오령효낭연합골화삼순대조기당뇨병신병( DN)환자뇨표기성단백적영향。방법：64례조기DN환자수궤분위대조조급관찰조각32례,량조균진행괄의음식급운동、단백질섭입량상대항정병우화강당방안,관찰조동시가복오령효낭(0.9 g, po tid)급골화삼순효환0.25μg, po qd,련속8주。관찰량조환자치료전후공복혈당( FBG)급찬후2 h 혈당(2hBG)、당화혈홍단백(HbA1c)、초민C반응단백(hs-CRP)、뇨총단백、뇨백단백배설량(Alb)、뇨β2미구단백(β2-MG),뇨시황순결합단백(RBP)등변화。결과：량조치료후FBG、2hBG、HbA1c、hs-CRP、뇨총단백、Alb급RBP치균교치료전명현개선,차이유통계학의의(P<0.05)；차관찰조치료후뇨총단백、Alb、β2-MG、RBP급hs-CRP치명현우우대조조(P<0.05)。결론：오령효낭연합골화삼순가유효감경조기DN환자신소구급신소관적손상。
Objective:To observe the effect of Wuling capsules combined with calcitriol on urine marker proteins in early diabetic nephropathy ( DN) . Methods: Totally 64 patients with early DN were randomly divided into the control group and the observation group with 32 cases in each. The two groups were with appropriate diet and exercise, relatively stable protein intake and optimal hypo-glycemic program. The observation group was additionally treated with Wuling capsules (0. 9 g, po tid) and calcitriol 0. 25 μg,po qd, with the treatment course of eight weeks. The levels of FBG and 2hBG, HbA1c, hs-CRP, urinary protein, ALB, β2-MG and RBP were observed in the two groups before and after the treatment. Results:After the treatment, FBG, 2hBG, HbA1c, hs-CRP, total pro-tein, Alb and RBP in the two groups were improved when compared with those before the treatment, and the difference had statistical significance(P<0. 05). The total protein, ALB,β2-MG, RBP and hs-CRP in the observation group were better than those in the con-trol group after the treatment, and the difference was statistically significance (P<0. 05). Conclusion: Wuling capsules combined with calcitriol can effectively reduce glomerular and renal tubular damage in early DN patients.
