浙江创伤外科
浙江創傷外科
절강창상외과
Zhejiang Journal of Traumatic Surgery
2015年
5期
844-847
,共4页
胃癌根治术%腹腔镜%开放手术%炎症反应%免疫功能
胃癌根治術%腹腔鏡%開放手術%炎癥反應%免疫功能
위암근치술%복강경%개방수술%염증반응%면역공능
Gastric cancer radical operation%Laparoscopy%Open operation%Inflammatory reaction%Immune function
目的 探讨腹腔镜与开腹胃癌根治术对机体炎性反应和免疫功能的影响. 方法 以2013年3月至2015年3月在本院进行手术医治的70例胃癌患者为研究对象,依据所采用手术方发的不同分为研究组(腹腔镜手术)和对照组(开腹手术),每组35例.对2组患者的临床疗效以及术前、术后2组患者的血清炎症指标和免疫指标进行比较. 结果 研究组在术中出血量、术后离床活动时间、第1次肛门排气时间、住院时间以及并发症发生率上均好于对照组(P<0.05);两组患者在术后1天、7天血清中CD3、CD4、CD4/CD8表达水平均较术前低,而CD8确高于术前(P<0.05);术后1天、7天血清中CD4,CD4/CD8、CD3的表达研究组均高于对照组,而CD8显著低于对照组(P<0.05);两组患者术后1天、7天血清中IL-6、CRP表达水平均较术前高,而IgG、IgM和IgA确低于术前(P<0.05);研究组术后1天、7天血清中IL-6、CRP表达水平均较对照组低,而IgG,IgM和IgA均高于对照(P<0.05). 结论 同开腹手术相比,腹腔镜胃癌根治术对机体造成的创伤小,对机体免疫功能和炎症反应的影响也较小,有利于机体的恢复,是一种安全可行、值得临床推广应用的术式.
目的 探討腹腔鏡與開腹胃癌根治術對機體炎性反應和免疫功能的影響. 方法 以2013年3月至2015年3月在本院進行手術醫治的70例胃癌患者為研究對象,依據所採用手術方髮的不同分為研究組(腹腔鏡手術)和對照組(開腹手術),每組35例.對2組患者的臨床療效以及術前、術後2組患者的血清炎癥指標和免疫指標進行比較. 結果 研究組在術中齣血量、術後離床活動時間、第1次肛門排氣時間、住院時間以及併髮癥髮生率上均好于對照組(P<0.05);兩組患者在術後1天、7天血清中CD3、CD4、CD4/CD8錶達水平均較術前低,而CD8確高于術前(P<0.05);術後1天、7天血清中CD4,CD4/CD8、CD3的錶達研究組均高于對照組,而CD8顯著低于對照組(P<0.05);兩組患者術後1天、7天血清中IL-6、CRP錶達水平均較術前高,而IgG、IgM和IgA確低于術前(P<0.05);研究組術後1天、7天血清中IL-6、CRP錶達水平均較對照組低,而IgG,IgM和IgA均高于對照(P<0.05). 結論 同開腹手術相比,腹腔鏡胃癌根治術對機體造成的創傷小,對機體免疫功能和炎癥反應的影響也較小,有利于機體的恢複,是一種安全可行、值得臨床推廣應用的術式.
목적 탐토복강경여개복위암근치술대궤체염성반응화면역공능적영향. 방법 이2013년3월지2015년3월재본원진행수술의치적70례위암환자위연구대상,의거소채용수술방발적불동분위연구조(복강경수술)화대조조(개복수술),매조35례.대2조환자적림상료효이급술전、술후2조환자적혈청염증지표화면역지표진행비교. 결과 연구조재술중출혈량、술후리상활동시간、제1차항문배기시간、주원시간이급병발증발생솔상균호우대조조(P<0.05);량조환자재술후1천、7천혈청중CD3、CD4、CD4/CD8표체수평균교술전저,이CD8학고우술전(P<0.05);술후1천、7천혈청중CD4,CD4/CD8、CD3적표체연구조균고우대조조,이CD8현저저우대조조(P<0.05);량조환자술후1천、7천혈청중IL-6、CRP표체수평균교술전고,이IgG、IgM화IgA학저우술전(P<0.05);연구조술후1천、7천혈청중IL-6、CRP표체수평균교대조조저,이IgG,IgM화IgA균고우대조(P<0.05). 결론 동개복수술상비,복강경위암근치술대궤체조성적창상소,대궤체면역공능화염증반응적영향야교소,유리우궤체적회복,시일충안전가행、치득림상추엄응용적술식.
Objective To discuss the effect of laparoscopic radical gastrectomy and open radical gastrectomy influence on inflammatory reaction and immune function for gastric cancer. Methods From March 2013 to March 2015 in our hospital, 70 patients with gastric cancer were treated with surgery were randomly divided into research group(laparoscopic) and control group(laparotomy),35 cases in each group. Clinical curative effect, preoperative and postoperative serum inflammatory biomarkers and immune indexes were compared. Results The intraoperative blood loss, postoperative bed time, first exhaust time, length of hospital stay, and complications in the research group were better than those in the control group( P<0.05). The postoperative CD3, CD4, CD4/CD8 after one day and seven days were significantly lower than those before surgery, CD8 was significantly higher than that before surgery( P<0. 05). The postoperative CD3,CD4,CD4/CD8 after one day and seven days in the research group were significantly higher,CD8 was significantly lower than those in the control group (P<0.05). The postoperative IL-6, CRP after one day and seven days were significantly higher than those before surgery.The post-operative IgG, IgM and IgA were significantly lower than those before surgery ( P<0.05). The postoperative IL-6, CRP after one day and seven days in the re-search group were significantly lower than those in the control group. The postoperative IgG,IgM and IgA were significantly higher than those in the control group (P<0.05). Conclusions Compared with open surgery, laparoscopic had small trauma, less postoperative complications and fast recovery, and had less postoperative inflammation.
