CAJ | 학술논문

目的：研究心脏移植术后患者血清中 IL-6的变化及其在疾病发展过程中的意义。方法分别在移植前及术后第1、3、7、14、30天抽取患者静脉血，采用双抗体夹心 ELISA 法检测血清中 IL-6浓度，并监测患者血清中 FK506药物浓度。结果心脏移植患者血清中 IL-6在术前与健康对照组人群无显著性差异（P ＞0．05），并在术后第一天明显升高（P ＜0．05），并于第3天开始降低，在术后第7天基本回复术前水平；移植急性排斥组患者血清中 IL-6浓度显著高于术前水平，在未发生排斥反应时，移植稳定组患者血清中 IL-6与术前无明显差异；移植急性排斥反应患者血清中 FK506浓度与 IL-6浓度呈现显著地负相关性（P ＜0．05）。结论IL-6在移植急性排斥反应病情的发展中起着重要作用，监测受者血清中 IL-6水平可预测急性排斥反应发生的风险。
목적：연구심장이식술후환자혈청중 IL-6적변화급기재질병발전과정중적의의。방법분별재이식전급술후제1、3、7、14、30천추취환자정맥혈，채용쌍항체협심 ELISA 법검측혈청중 IL-6농도，병감측환자혈청중 FK506약물농도。결과심장이식환자혈청중 IL-6재술전여건강대조조인군무현저성차이（P ＞0．05），병재술후제일천명현승고（P ＜0．05），병우제3천개시강저，재술후제7천기본회복술전수평；이식급성배척조환자혈청중 IL-6농도현저고우술전수평，재미발생배척반응시，이식은정조환자혈청중 IL-6여술전무명현차이；이식급성배척반응환자혈청중 FK506농도여 IL-6농도정현현저지부상관성（P ＜0．05）。결론IL-6재이식급성배척반응병정적발전중기착중요작용，감측수자혈청중 IL-6수평가예측급성배척반응발생적풍험。
Objective To study the change and clinical significance of serum IL-6 in patients with heart transplanta-tion.Methods Serum IL-6 was detected before and post transplantation on day 1,3,7,14,30 with ELISA.The level of Serum FK506 was measured on and off.Results There were no significant difference existed in the levels of serum IL-6 in pre-transplantation patients compared to those of control group respectively(p>0.05).After operation,the levels of serum IL-6 on day 1 in patients were significantly higher,and dropper to the nadir on day 3,then rose to pre-opera-tive values on day 7.These results indicated that the level of FK506 was negatively correlated with the level of serum IL-6.Conclusion IL-6 may play an important role in the development of post-transplanted rejection of patients,and could be an useful markers to monitor the level of immunosuppressant after cardiac transplantation.