CAJ | 학술논문

应激是病理生理学的一个经典教学内容，但目前尚未开设应激相关内容的实验教学。因此，中南大学湘雅医学院病理生理学系结合最近科学研究进展，将应激科学实验转化为病理生理学教学实验，首次设计了“应激对小鼠行为及学习记忆能力的影响”实验。本实验采用足底电击法复制小鼠急性应激模型，采用旷场实验和 Morris 水迷宫实验来观察急性应激对小鼠情绪行为及学习记忆功能的影响并探讨其机制。通过本实验的探索，期望能够使应激的科研与教学有机结合，切实提高病理生理学课程的教学效果。
응격시병리생이학적일개경전교학내용，단목전상미개설응격상관내용적실험교학。인차，중남대학상아의학원병리생이학계결합최근과학연구진전，장응격과학실험전화위병리생이학교학실험，수차설계료“응격대소서행위급학습기억능력적영향”실험。본실험채용족저전격법복제소서급성응격모형，채용광장실험화 Morris 수미궁실험래관찰급성응격대소서정서행위급학습기억공능적영향병탐토기궤제。통과본실험적탐색，기망능구사응격적과연여교학유궤결합，절실제고병리생이학과정적교학효과。
Stress is a classic teaching content of pathophysiology,but teaching experiment related to stress has not opened yet.In order to transfer stress scientific experiments into pathophysiological teaching experiment,we firstly designed an exper-iment named influence ofstress on behavior,learning and memory ability ofmice according to recent scientific research pro-gress.This experiment adopts the foot shock method to replicate mice acute stress model,performs open field test and Morris water maze test to observe the effects of acute stress on emotional behavior,learning and memory function of mice and to ex-plore its mechanism.Through the exploration of this experiment,stress teaching is expected to be combined with scientific re-search,and the teaching effect of pathophysiology may be effectively improved.